文章：

癌症中的Ca²⁺信号检查点：重塑Ca²⁺对癌细胞增殖和存活的影响

Ca²⁺ signalling checkpoints in cancer: remodelling Ca²⁺ for cancer cell proliferation and survival

原文发布日期：2008-05-01

DOI: 10.1038/nrc2374

类型: Review Article

开放获取: 否

要点：

1. Changes in Ca²⁺ levels are versatile and dynamic signalling events that control diverse cellular events over a wide range of timescales.
2. Tumour cells are characterized by their acquisition of different physiological traits that allow them to proliferate independently of growth signals and avoid appropriate cell death.
3. The Ca²⁺ signalling 'toolkit' — that is, the proteins involved in regulating Ca²⁺ signalling — is often remodelled in tumour cells to sustain proliferation and avoid cell death.
4. Ca²⁺ signalling proteins and organelles are emerging as additional cellular targets of oncogenes and tumour suppressors.
5. Ca²⁺ signalling pathways remodelled in cancer provide novel opportunities for therapeutic intervention.

要点翻译：

1. 钙离子水平的变化是多功能且动态的信号事件，控制着不同时间尺度下的多种细胞活动。
2. 肿瘤细胞的特征在于其获得不同的生理特性，使其能够独立于生长信号进行增殖并避免适当的细胞死亡。
3. 钙信号"工具箱"——即参与调节钙信号的蛋白质——常在肿瘤细胞中被重塑以维持增殖并逃避细胞死亡。
4. 钙信号蛋白和细胞器正逐渐成为癌基因和肿瘤抑制因子的新细胞靶点。
5. 癌症中被重塑的钙信号通路为治疗干预提供了新的机遇。

英文摘要：

Increases in cytosolic free Ca²⁺([Ca²⁺]i) represent a ubiquitous signalling mechanism that controls a variety of cellular processes, including proliferation, metabolism and gene transcription, yet under certain conditions increases in intracellular Ca²⁺ are cytotoxic. Thus, in using Ca²⁺ as a messenger, cells walk a tightrope in which [Ca²⁺]i is strictly maintained within defined boundaries. To adhere to these boundaries and to sustain their modified phenotype, many cancer cells remodel the expression or activity of their Ca²⁺ signalling apparatus. Here, we review the role of Ca²⁺ in promoting cell proliferation and cell death, how these processes are remodelled in cancer and the opportunities this might provide for therapeutic intervention.

摘要翻译： 

胞浆游离钙离子（[Ca²⁺]ᵢ）升高是一种普遍存在的信号机制，调控细胞增殖、代谢及基因转录等多种过程；然而在某些条件下，胞内钙离子升高又具有细胞毒性。因此，细胞在利用钙离子作为信使时，必须“走钢丝”，将[Ca²⁺]ᵢ严格维持在限定范围内。为遵守这一边界并维持其已改变的表型，许多癌细胞会重塑其钙离子信号装置的表达或活性。本文综述钙离子在促进细胞增殖与死亡中的作用、这些过程在癌症中的重塑，以及由此可能带来的治疗干预机会。

原文链接：

Ca²⁺ signalling checkpoints in cancer: remodelling Ca²⁺ for cancer cell proliferation and survival