文章：

多梳消声器控制着细胞的命运、发育和癌症

Polycomb silencers control cell fate, development and cancer

原文发布日期：2006-11-01

DOI: 10.1038/nrc1991

类型: Review Article

开放获取: 否

要点：

1. Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and progression of human cancer.
2. Polycomb group (PcG) proteins regulate epigenetically mediated transcriptional silencing. They are involved in the maintenance of embryonic and adult stem cells and have been implicated in cancer development.
3. PcG-mediated repression of key tumour-suppressor pathways, as well as their role in the regulation of stem cell maintenance might contribute to their oncogenic function.
4. The recent global identification of PcG target genes provides the first insights into the mechanisms that govern stem cell maintenance and imply a dynamic regulation of PcG function during differentiation.

要点翻译：

1. 表观遗传基因沉默是导致基因功能丧失的重要机制，并与遗传突变协同作用参与人类癌症的发生与发展。
2. 多梳家族蛋白通过表观遗传机制介导转录沉默。它们参与胚胎和成人干细胞的维持，并与癌症发展密切相关。
3. 多梳家族蛋白通过抑制关键肿瘤抑制通路，以及在调控干细胞维持中的作用，可能促进其致癌功能的实现。
4. 近期对多梳家族靶向基因的全局性研究，首次揭示了调控干细胞维持的分子机制，并表明多梳家族功能在分化过程中受到动态调控。

英文摘要：

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.

摘要翻译： 

多梳家族（PcG）蛋白是表观遗传学中的基因沉默因子，与肿瘤发生发展密切相关。其致癌作用可能与其在胚胎干细胞和成体干细胞维持中已确立的功能有关。在本综述中，我们探讨了PcG调控细胞身份的可能机制的新见解，并推测这些功能在肿瘤发生中的潜在意义。

原文链接：

Polycomb silencers control cell fate, development and cancer