文章：

光动力疗法与抗肿瘤免疫

Photodynamic therapy and anti-tumour immunity

原文发布日期：2006-07-01

DOI: 10.1038/nrc1894

类型: Review Article

开放获取: 否

要点：

1. Photodynamic therapy (PDT) uses non-toxic dyes and harmless visible light in combination with oxygen to produce highly reactive oxygen species that kill cells.
2. In addition to destroying tumour tissue by a process that can produce cellular necrosis and the expression of stress proteins, PDT produces an acute inflammation, and attracts leukocytes to treated tumours.
3. PDT might increase the immunogenicity of dead tumour cells by exposing or creating new antigens, and by inducing heat-shock proteins that increase the efficiency of antigen cross-presentation to form more effective tumour-specific cytotoxic T cells.
4. The pro-inflammatory effects of PDT might increase dendritic-cell migration, antigen uptake and maturation.
5. PDT can produce tumour cures and long-lasting tumour-specific immunity (memory), as has been shown by the rejection of tumours on rechallenge in certain mouse and rat models.
6. PDT has been combined with a range of immunostimulatory therapies, including microbial adjuvants, to increase the anti-tumour immunity produced by PDT alone.
7. There are only a few reports of the immunostimulatory effects of PDT in humans, but increasing recognition of the effect should lead to further work and possibly to improved patient outcome.

要点翻译：

1. 光动力疗法（PDT）通过联合使用无毒染料、无害可见光及氧气，产生活性氧簇杀伤细胞。
2. 该疗法不仅能通过诱导细胞坏死和应激蛋白表达破坏肿瘤组织，还会引发急性炎症并吸引白细胞聚集于处理后的肿瘤部位。
3. PDT可能通过暴露或创造新抗原，以及诱导热休克蛋白增强抗原交叉呈递效率，形成更有效的肿瘤特异性细胞毒性T细胞，从而增强死亡肿瘤细胞的免疫原性。
4. 其促炎效应可促进树突状细胞迁移、抗原摄取与成熟。
5. 研究表明，在某些小鼠和大鼠模型中，PDT可实现肿瘤治愈并诱导长效肿瘤特异性免疫记忆（表现为再次接种肿瘤时出现排斥反应）。
6. 目前PDT已与多种免疫刺激疗法（包括微生物佐剂）联用，以增强其单独使用时的抗肿瘤免疫力。
7. 虽然关于PDT对人体免疫刺激作用的报道有限，但随着该效应日益受到关注，相关研究将逐步深入，并有望改善患者预后。

英文摘要：

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

摘要翻译： 

光动力疗法（PDT）利用无毒的光敏剂与无害的可见光，在氧气存在下产生具有细胞毒性的活性氧，通过凋亡和/或坏死杀死恶性细胞，关闭肿瘤微血管并刺激宿主免疫系统。与手术、放疗和化疗主要具有免疫抑制作用不同，PDT可引发急性炎症、热休克蛋白表达、白细胞对肿瘤的侵袭与浸润，并可能增强肿瘤抗原向T细胞的呈递。

原文链接：

Photodynamic therapy and anti-tumour immunity