文章：

癌症治疗中的药物相互作用

Drug interactions in cancer therapy

原文发布日期：2006-07-01

DOI: 10.1038/nrc1887

类型: Review Article

开放获取: 否

要点：

1. Drug–drug interactions are an important concern in the treatment of cancer. They can affect drug dosage, which is important for optimizing the anti-tumour effect of treatments and minimizing their toxicity to normal tissue.
2. Interactions can occur between drugs and other drugs, food or herbal supplements, and can also be affected by a patient's genetic composition and physiological status. Most pharmacokinetic drug interactions involve drug metabolism and/or transport as a mechanistic basis. Therefore, it is important to understand the role of human enzymes and transporters in the metabolism and disposition of antineoplastic agents, as well as the mechanisms by which antineoplastics modulate the expression and activity of human enzymes and transporters.
3. Pharmacodynamic drug interactions could be the result of overlapping mechanisms of action or combined toxicities to the same target organ. These interactions could be used to increase the therapeutic effect of a combination regimen or to minimize its toxicity.
4. It is important that potential drug interactions are identified early in the drug-development process, and this might be made possible by improvements in in vitro model systems.

要点翻译：

1. 药物相互作用在癌症治疗中是一个重要问题。它们会影响药物剂量，而剂量优化对于提升治疗的抗肿瘤效果及减轻对正常组织的毒性至关重要。
2. 相互作用可能发生在药物与其它药物、食物或草药补充剂之间，同时也会受到患者基因构成和生理状态的影响。大多数药代动力学药物相互作用以药物代谢和/或转运为机制基础。因此，理解人类酶系统和转运体在抗肿瘤药物代谢与分布中的作用，以及抗肿瘤药物调节这些酶系统和转运体表达与活性的机制具有重要意义。
3. 药效学药物相互作用可能源于重叠的作用机制或对同一靶器官的复合毒性。这类相互作用可用于增强联合疗法的治疗效果，或降低其毒性反应。
4. 在药物研发早期阶段识别潜在药物相互作用至关重要，而体外模型系统的改进使这一目标成为可能。

英文摘要：

Drug interactions in oncology are of particular importance owing to the narrow therapeutic index and the inherent toxicity of anticancer agents. Interactions with other medications can cause small changes in the pharmacokinetics or pharmacodynamics of a chemotherapy agent that could significantly alter its efficacy or toxicity. Improvements in in vitro methods and early clinical testing have made the prediction of potentially clinically significant drug interactions possible. We outline the types of drug interaction that occur in oncology, the mechanisms that underlie these interactions and describe select examples.

摘要翻译： 

肿瘤药物相互作用尤为重要，因为抗癌药物的治疗指数狭窄且具有固有毒性。与其他药物的相互作用可能导致化疗药物的药代动力学或药效学发生微小变化，从而显著改变其疗效或毒性。体外方法和早期临床测试的改进使得预测潜在具有临床意义的药物相互作用成为可能。我们概述了肿瘤学中发生的药物相互作用类型、这些相互作用背后的机制，并描述了一些精选实例。

原文链接：

Drug interactions in cancer therapy