文章：

雌激素和SERMs在子宫内膜癌发生中的分子机制

Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis

原文发布日期：2006-05-01

DOI: 10.1038/nrc1879

类型: Review Article

开放获取: 否

要点：

1. Endometrial cancer is the most common gynaecological malignancy.
2. Although no specific gene or genes have been linked to the majority of cases of endometrial cancer, several well-characterized oncogenes and tumour-suppressor genes have been implicated in endometrial carcinogenesis.
3. Approximately 80% of endometrial cancer cases are type I tumours, which are usually well differentiated and endometrioid in histology, and are associated with a history of unopposed oestrogen exposure or other hyperoestrogenic risk factors such as obesity.
4. Oestrogen and selective oestrogen-receptor modulators (SERMs) are implicated in endometrial carcinogenesis through regulation of gene transcription.
5. Oestrogen and SERMs exert their carcinogenic roles in the endometrium through their downstream molecular effectors such as PAX2 (paired box gene 2).

要点翻译：

1. 子宫内膜癌是最常见的妇科恶性肿瘤。
2. 尽管大多数子宫内膜癌病例尚未发现特定的基因关联，但已有几种明确表征的癌基因和肿瘤抑制基因被证实与子宫内膜癌发生有关。
3. 约80%的子宫内膜癌病例属于I型肿瘤，这类肿瘤通常组织学上分化良好且呈子宫内膜样形态，与长期无孕激素拮抗的雌激素暴露史或其他高雌激素风险因素（如肥胖）相关。
4. 雌激素和选择性雌激素受体调节剂通过调控基因转录参与子宫内膜癌的发生。
5. 雌激素和选择性雌激素受体调节剂通过其下游分子效应物（如PAX2）在子宫内膜中发挥致癌作用。

英文摘要：

Endometrial cancer is the most common gynaecological cancer, and is associated with endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast cancer using selective oestrogen-receptor modulators (SERMs), particularly tamoxifen. Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation. Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).

摘要翻译： 

子宫内膜癌是最常见的妇科恶性肿瘤，与子宫内膜增生、单一雌激素暴露以及使用选择性雌激素受体调节剂（SERMs，特别是他莫昔芬）作为乳腺癌的辅助治疗有关。雌激素和SERMs被认为通过其对转录调控的影响参与子宫内膜癌变过程。最终，雌激素和SERMs通过下游效应因子如PAX2（配对盒2）影响细胞信号转导通路，这些通路调控细胞的生长和增殖。

原文链接：

Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis