文章：

癌症中的成纤维细胞

Fibroblasts in cancer

原文发布日期：2006-03-30

DOI: 10.1038/nrc1877

类型: Review Article

开放获取: 否

要点：

1. Fibroblasts are a key cellular component of tumours.
2. Activated fibroblasts (which are sometimes referred to as myofibroblasts) that are found in association with cancer cells are known as carcinoma-associated fibroblasts (CAFs).
3. The role of fibroblasts in the origin and initiation of cancer invasion is poorly understood, but recent evidence indicates that they can provide oncogenic signals to the transformed epithelia in a paracrine fashion.
4. Some studies indicate that myofibroblasts might facilitate angiogenesis and cancer progression.
5. Epithelial-to-mesenchymal transition is a source for converting epithelial cells into fibroblast-like cells in various tissues.
6. Fibroblasts might also have a role in metastasis.
7. Therapies against CAFs are being considered as a way to control cancer.

要点翻译：

1. 成纤维细胞是肿瘤的关键细胞成分。
2. 与癌细胞相关的活化成纤维细胞（有时称为肌成纤维细胞）被称为癌症相关成纤维细胞（CAF）。
3. 人们对成纤维细胞在癌症侵袭起源和启动中的作用了解甚少，但最新证据表明它们能通过旁分泌方式向转化上皮细胞提供致癌信号。
4. 一些研究表明肌成纤维细胞可能促进血管生成和癌症进展。
5. 上皮-间质转化是各种组织中上皮细胞转化为成纤维样细胞的来源。
6. 成纤维细胞可能在转移中也发挥作用。
7. 针对CAF的疗法正被视为控制癌症的一种途径。

英文摘要：

Tumours are known as wounds that do not heal — this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.

摘要翻译： 

肿瘤被称为“无法愈合的伤口”——这意味着参与血管生成和损伤反应的细胞（如内皮细胞和成纤维细胞）在癌症的进展、生长和扩散中发挥着重要作用。成纤维细胞在癌症进展的所有阶段都与癌细胞相关联，它们在这一过程中的结构和功能贡献正逐渐显现。它们通过产生生长因子、趋化因子和细胞外基质，促进内皮细胞和周细胞的血管生成募集。因此，成纤维细胞是癌症恶性进展的关键决定因素，也是癌症治疗的重要靶点。

原文链接：

Fibroblasts in cancer