文章：

整合素在鳞状细胞癌中的新作用

New roles for integrins in squamous-cell carcinoma

原文发布日期：2006-02-16

DOI: 10.1038/nrc1817

类型: Review Article

开放获取: 否

要点：

1. Squamous-cell carcinomas arise from the stratified epithelia of several organs such as the epidermis, oral cavity and oesophagus. Patient prognosis depends on early detection before metastasis, and surgery remains the best chance of cure.
2. Integrin expression is known to predict survival, but new data indicates that rare, activating integrin mutations might also affect tumour behaviour.
3. In tumours, altered integrin expression can provide a growth advantage by protecting from apoptosis. Upregulation of different integrins promotes proliferation and invasion.
4. Abnormal integrin expression on differentiated cells can regulate the clonal expansion of cancers generated from neighbouring progenitor cells.
5. Skin inflammation can be triggered by aberrant integrin expression, contributing to tumour susceptibility.

要点翻译：

1. 鳞状细胞癌起源于多个器官的复层上皮，如表皮、口腔和食管。患者预后取决于转移前的早期发现，而手术仍是治愈的最佳机会。
2. 整合素表达已知可预测生存率，但新数据表明罕见的激活型整合素突变也可能影响肿瘤行为。
3. 在肿瘤中，整合素表达的改变可通过抗凋亡作用提供生长优势。不同整合素的上调促进增殖和侵袭。
4. 分化细胞上的异常整合素表达可调控邻近祖细胞所产生癌症的克隆扩增。
5. 皮肤炎症可由整合素表达异常引发，从而增加肿瘤易感性。

英文摘要：

Although integrins are known to mediate invasion and metastasis, recent studies reveal new ways in which they contribute to squamous-cell carcinoma. Integrin mutation or upregulation can expand the tumour stem-cell compartment by inhibiting differentiation or apoptosis. Integrins that are expressed by differentiated cells can stimulate or inhibit the proliferation of neighbouring tumour stem cells. These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis.

摘要翻译： 

尽管已知整合素介导侵袭和转移，但最新研究揭示了它们对鳞状细胞癌的新作用机制。整合素突变或上调可通过抑制分化或凋亡来扩大肿瘤干细胞库。由分化细胞表达的整合素能够刺激或抑制邻近肿瘤干细胞的增殖。这些发现为整合素表达改变与肿瘤预后之间已确立的关联提供了机制性基础。

原文链接：

New roles for integrins in squamous-cell carcinoma