文章：

癌症中的螺旋-环-螺旋蛋白家族

Id family of helix-loop-helix proteins in cancer

原文发布日期：2005-07-20

DOI: 10.1038/nrc1673

类型: Review Article

开放获取: 否

要点：

1. Inhibitor of DNA binding (Id) family members are key regulatory proteins in a wide range of developmental and cellular processes and function by inhibiting target proteins that include the basic helix-loop-helix transcription factors, members of the Ets protein family and retinoblastoma.
2. Ids serve as downstream targets of known oncogenic pathways. However, the characterization of Id expression in human tumours and mouse models of cancer requires more careful analysis.
3. Ids can contribute to tumorigenesis by inhibiting cell differentiation, stimulating proliferation and facilitating tumour neoangiogenesis.
4. Id overexpression might mimic the activity of other oncogenes or the loss of tumour suppressor activity.
5. The low postnatal expression of the Ids and their roles in tumorigenesis and tumour neoangiogenesis mark them as attractive targets for anti-cancer therapy.

要点翻译：

1. DNA结合抑制因子（Id）家族成员是多种发育和细胞过程的关键调控蛋白，通过抑制包括碱性螺旋-环-螺旋转录因子、Ets蛋白家族成员和视网膜母细胞瘤蛋白在内的靶蛋白发挥作用。
2. Ids可作为已知致癌通路的下游靶点。然而，对人类肿瘤及小鼠癌症模型中Id表达的特征分析仍需更深入的研究。
3. Ids通过抑制细胞分化、刺激增殖和促进肿瘤新生血管形成等方式参与肿瘤发生。
4. Id的过表达可能模拟其他癌基因的活性或抑癌基因功能的丧失。
5. Ids在出生后的低表达水平及其在肿瘤发生和肿瘤新生血管形成中的作用，使其成为抗癌治疗中极具吸引力的靶点。

英文摘要：

Over the past few decades, biologists have identified key molecular signatures associated with a wide range of human cancers. Recently, animal models have been particularly useful in establishing whether such signatures have functional relevance; the overexpression of pro-oncogenic or loss of anti-oncogenic factors have been evaluated for their effects on various tumour models. The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.

摘要翻译： 

在过去几十年里，生物学家已鉴定出与多种人类癌症相关的关键分子特征。近期，动物模型在验证这些特征是否具有功能意义方面尤为有用；通过过表达促癌因子或敲除抑癌因子，研究其在多种肿瘤模型中的效应。本综述旨在分析DNA结合抑制蛋白（Id蛋白）在癌症中的潜在作用，并探讨Id活性失调是否具有致瘤性，以及是否促进恶性肿瘤特征，如分化丧失（间变）、无限增殖和新生血管生成。

原文链接：

Id family of helix-loop-helix proteins in cancer