文章：

B细胞淋巴瘤的发病机制

Mechanisms of B-cell lymphoma pathogenesis

原文发布日期：2005-04-01

DOI: 10.1038/nrc1589

类型: Review Article

开放获取: 否

要点：

1. A hallmark of many types of B-cell lymphoma is reciprocal chromosomal translocations involving one of the immunoglobulin loci and a proto-oncogene. As a consequence of such translocations, the oncogene comes under the control of an active immunoglobulin locus, causing deregulated, constitutive expression of the translocated gene.
2. Normal B cells depend on B-cell receptor (BCR) expression for survival. The selection for expression of a BCR also seems to operate in most malignant B cells.
3. Although there is strong evidence that most B-cell lymphomas depend on BCR expression, there are a few exceptions — namely classical Hodgkin's lymphoma, primary mediastinal B-cell lymphoma, some post-transplant lymphomas, and the rare primary effusion lymphomas.
4. In several lymphomas, there is a strong indication that the lymphoma cells recognize an antigen and that stimulation by antigen binding contributes to the survival and proliferation of lymphoma cells.
5. In many lymphomas, such as follicular lymphoma, mucosa-associated lymphoid tissue lymphomas and classical Hodgkin's lymphoma, the tumour microenvironment seems to be important for the survival and/or proliferation of the lymphoma cells.
6. The recognition that the survival and/or proliferation of many B-cell lymphomas depends on their interaction with other cells in the microenvironment, as well as on expression of the B-cell receptor and, sometimes, antigen activation, might lead to novel treatment options for B-cell lymphomas.

要点翻译：

1. 许多类型B细胞淋巴瘤的一个典型特征是涉及某个免疫球蛋白基因位点与原癌基因的相互染色体易位。此类易位使原癌基因受控于活性免疫球蛋白基因位点，导致易位基因出现不受调控的持续性表达。
2. 正常B细胞的存活依赖于B细胞受体（BCR）的表达。这种对BCR表达的选择机制在大多数恶性B细胞中同样存在。
3. 尽管有充分证据表明大多数B细胞淋巴瘤依赖BCR表达，但仍存在少数例外——即经典型霍奇金淋巴瘤、原发性纵隔B细胞淋巴瘤、部分移植后淋巴瘤以及罕见的原发性渗出性淋巴瘤。
4. 有强烈迹象表明，在多种淋巴瘤中，淋巴瘤细胞能够识别抗原，且抗原结合刺激有助于淋巴瘤细胞的存活和增殖。
5. 在滤泡性淋巴瘤、黏膜相关淋巴组织淋巴瘤和经典型霍奇金淋巴瘤等许多淋巴瘤中，肿瘤微环境似乎对淋巴瘤细胞的存活和/或增殖至关重要。
6. 认识到许多B细胞淋巴瘤的存活和/或增殖取决于其与微环境中其他细胞的相互作用、B细胞受体的表达以及有时抗原的激活，可能为B细胞淋巴瘤带来新的治疗选择。

英文摘要：

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies.

摘要翻译： 

涉及免疫球蛋白基因位点的染色体易位是多种B细胞淋巴瘤的标志特征。然而，其他因素在B细胞恶性肿瘤的发病机制中也起着重要作用。大多数B细胞淋巴瘤依赖B细胞受体（BCR）的表达以维持生存，并且在几种B细胞恶性肿瘤中，通过BCR信号传导的抗原激活似乎是淋巴瘤发病机制中的一个重要因素。近年来，关于微环境提供的因素在淋巴瘤发生中作用的新见解，也为治疗策略提供了新的方向。

原文链接：

Mechanisms of B-cell lymphoma pathogenesis