文章：

成骨细胞在前列腺癌骨转移中的作用

Osteoblasts in prostate cancer metastasis to bone

原文发布日期：2005-01-01

DOI: 10.1038/nrc1528

类型: Review Article

开放获取: 否

要点：

1. Patients with advanced prostate cancer frequently develop bone metastases.
2. The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of interactions between prostate cancer cells and osteoblasts. Prostate cancer cells might depend on an osteoblast-derived factor for their growth.
3. Prostate cancer cells produce factors that perturb the bone microenvironment in ways that affect the normal functional balance between osteoblast and osteoclast activities, resulting in osteoblastic metastases.
4. Osteoblasts also secrete factors that facilitate progression of prostate cancer in bone.
5. Therapeutics designed to target the interaction between prostate cancer and osteoblasts might prevent or treat prostate cancer bone metastases.

要点翻译：

1. 晚期前列腺癌患者常发生骨转移。
2. 前列腺癌细胞对骨的亲和性及其诱导成骨细胞表型的倾向，是前列腺癌细胞与成骨细胞相互作用的结果。前列腺癌细胞的生长可能依赖于某种成骨细胞源性因子。
3. 前列腺癌细胞产生的因子会扰乱骨微环境，影响成骨细胞与破骨细胞活动之间的正常功能平衡，从而导致成骨性转移。
4. 成骨细胞亦分泌促进前列腺癌在骨中进展的因子。
5. 针对前列腺癌与成骨细胞相互作用设计的治疗方法可能预防或治疗前列腺癌骨转移。

英文摘要：

Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically detectable site of metastasis, and the resulting tumours tend to be osteoblastic (bone forming) rather than osteolytic (bone lysing). The interaction between host cells and metastatic cancer cells is an important component of organ-specific cancer progression. How can this knowledge lead to the development of more effective therapies?

摘要翻译： 

骨转移常见于肺癌、肾癌、乳腺癌和前列腺癌。然而，前列腺癌的独特之处在于，骨往往是唯一临床可检测到的转移部位，且所形成的肿瘤多为成骨性（促进骨形成），而非溶骨性（破坏骨组织）。宿主细胞与转移性癌细胞之间的相互作用，是器官特异性癌症进展的重要组成部分。如何利用这一认识，开发更有效的治疗策略？

原文链接：

Osteoblasts in prostate cancer metastasis to bone