文章：

半凝集素作为肿瘤进展的调节剂

Galectins as modulators of tumour progression

原文发布日期：2005-01-01

DOI: 10.1038/nrc1527

类型: Review Article

开放获取: 否

要点：

1. Galectins are a family of animal lectins that have affinity for β-galactosides and that share similar amino-acid sequences.
2. Galectins bind to a wide array of glycoproteins and glycolipids both on the cell surface and in extracellular matrices.
3. By binding to these glycoconjugates, galectins deliver signals intracellularly as well as mediate cell–cell and cell–extracellular matrix adhesion.
4. The most extensively-studied function of galectins is the regulation of apoptosis; some galectins can induce apoptosis when added exogenously to cells, whereas others regulate apoptosis through intracellular mechanisms.
5. Galectin-1 and galectin-3 can interact with oncogenic Ras and mediate cell transformation induced by this oncogene.
6. Galectins can modulate cell adhesion and cell migration, thereby affecting the process of tumour metastasis.
7. Galectin-3 has angiogenic activity.
8. Galectins have pro- and anti-inflammatory functions and modulate the immune response. Furthermore, galectin-1 functions as a soluble mediator employed by tumour cells to evade the immune response.

要点翻译：

1. 半乳糖凝集素是一类对β-半乳糖苷具有亲和力且具有相似氨基酸序列的动物凝集素家族。
2. 半乳糖凝集素可与细胞表面及细胞外基质中的多种糖蛋白和糖脂结合。
3. 通过这些糖复合物的结合，半乳糖凝集素既能向细胞内传递信号，也能介导细胞-细胞及细胞-细胞外基质的粘附。
4. 其研究最深入的功能是调控细胞凋亡：某些半乳糖凝集素外源性添加至细胞时可诱导凋亡，而其他成员则通过细胞内机制调节凋亡。
5. 半乳糖凝集素-1和半乳糖凝集素-3可与致癌Ras相互作用，并介导该癌基因诱导的细胞转化。
6. 半乳糖凝集素能够调节细胞粘附与细胞迁移，从而影响肿瘤转移过程。
7. 半乳糖凝集素-3具有促血管生成活性。
8. 半乳糖凝集素兼具促炎和抗炎功能，并可调节免疫反应。此外，半乳糖凝集素-1作为肿瘤细胞采用的可溶性介质，可帮助肿瘤细胞逃避免疫反应。

英文摘要：

Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, by interacting with cytoplasmic and nuclear proteins to modulate signalling pathways. Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis. They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology?

摘要翻译： 

半乳凝素是一类具有多种生物学活性的动物凝集素。它们既在细胞外通过与细胞表面及细胞外基质中的糖蛋白和糖脂相互作用，也在细胞内通过与胞质和核内蛋白相互作用来调节信号通路。当前研究表明，半乳凝素在癌症中发挥重要作用；它们参与肿瘤转化、肿瘤细胞存活、血管生成及肿瘤转移。它们还能调节免疫和炎症反应，并可能在帮助肿瘤逃避免疫监视方面起关键作用。半乳凝素家族的不同成员如何在这些肿瘤生物学的不同方面中发挥作用？

原文链接：

Galectins as modulators of tumour progression