文章：

高间质液压力-癌症治疗的障碍

High interstitial fluid pressure — an obstacle in cancer therapy

原文发布日期：2004-10-01

DOI: 10.1038/nrc1456

类型: Review Article

开放获取: 否

要点：

1. Transcapillary flow, which is important for tissue homeostasis, is influenced by the hydrostatic and colloid osmotic pressures of capillaries and interstitium.
2. The interstitial fluid pressure (IFP) of normal tissues is actively regulated through interactions between stromal cells and the extracellular-matrix molecules.
3. Most solid tumours have increased IFP.
4. The reasons for increased tumour IFP include blood-vessel leakiness, lymph-vessel abnormalities, interstitial fibrosis and a contraction of the interstitial matrix mediated by stromal fibroblasts.
5. Increased tumour IFP causes inefficient uptake of therapeutic agents.
6. Lowering of tumour IFP — for example, by certain cytokine antagonists — can improve drug uptake and thereby improve treatment efficiency.

要点翻译：

1. 跨毛细血管流动对组织稳态至关重要，受毛细血管和组织间隙的静水压及胶体渗透压影响。
2. 正常组织的间质流体压力（IFP）通过基质细胞与细胞外基质分子间的相互作用进行主动调节。
3. 大多数实体肿瘤的IFP会升高。
4. 肿瘤IFP升高的原因包括血管渗漏、淋巴管异常、间质纤维化以及基质成纤维细胞介导的间质基质收缩。
5. 肿瘤IFP升高会导致治疗药物吸收效率低下。
6. 降低肿瘤IFP（例如通过某些细胞因子拮抗剂）可改善药物吸收，从而提高治疗效率。

英文摘要：

Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.

摘要翻译： 

许多实体瘤表现出间质流体压力（IFP）升高，形成跨毛细血管运输的屏障。这一障碍阻碍了肿瘤治疗，导致治疗药物摄取效率低下。肿瘤IFP升高的因素众多，包括血管异常、纤维化及间质基质收缩。使用特定信号转导拮抗剂降低肿瘤IFP，可能是提高抗癌药物疗效的有用策略。

原文链接：

High interstitial fluid pressure — an obstacle in cancer therapy