文章：

C/EBPα在急性髓性白血病中的突变

C/EBPα mutations in acute myeloid leukaemias

原文发布日期：2004-05-01

DOI: 10.1038/nrc1363

类型: Review Article

开放获取: 否

要点：

1. CCAAT/enhancer-binding protein-α (C/EBPα) is a transcription factor that coordinates cellular differentiation with growth arrest.
2. Patients with acute myeloid leukaemia carry specific combinations of point mutations in the gene encoding C/EBPα.
3. C/EBPα represses the E2F transcription factor. Patient-derived C/EBPα mutants generally loose the ability to bind DNA or to repress E2F activity.
4. C/EBPα expression inhibits the malignant potential of myeloid leukaemia cells by inducing their differentiation.
5. E2F repression and DNA binding by C/EBPα are required for the C/EBP-induced differentiation of leukaemia cells.
6. Reconstituting C/EBPα-mediated E2F repression has the potential to revert leukaemogenesis in vivo.

要点翻译：

1. CCAAT/增强子结合蛋白-α（C/EBPα）是一种协调细胞分化与生长停滞的转录因子。
2. 急性髓系白血病患者在编码C/EBPα的基因中携带特定组合的点突变。
3. C/EBPα可抑制E2F转录因子活性，而患者来源的C/EBPα突变体通常丧失DNA结合能力或抑制E2F活性的功能。
4. C/EBPα表达通过诱导髓系白血病细胞分化来抑制其恶性潜能。
5. C/EBPα对E2F的抑制及其DNA结合能力是诱导白血病细胞分化的必要条件。
6. 重建C/EBPα介导的E2F抑制机制具有在体内逆转白血病发生的潜力。

英文摘要：

Specific mutations in the gene that encodes the multifunctional transcription factor C/EBPα are frequently associated with acute myeloid leukaemias. Are only a specific subset of the functions of C/EBPα therefore involved in leukaemogenesis?

摘要翻译： 

编码多功能转录因子 C/EBPα 的基因发生特定突变，常与急性髓系白血病相关。因此，是否只有 C/EBPα 的部分特定功能参与了白血病的发生？

原文链接：

C/EBPα mutations in acute myeloid leukaemias