文章：

粘膜炎的病理生物学

The pathobiology of mucositis

原文发布日期：2004-04-01

DOI: 10.1038/nrc1318

类型: Review Article

开放获取: 否

要点：

1. Mucositis is a common toxicity of antineoplastic radiation and drug therapies, and is associated with several adverse symptomatic, health and economic outcomes.
2. There is no effective way to prevent or treat mucositis at present.
3. Understanding of the pathobiology of mucositis has increased rapidly during the past decade.
4. Mucositis is a biologically complex process that involves a dynamic, interactive sequence of panmucosal events that ultimately targets epithelial stem cells.
5. Several mechanistically based anti-mucositis agents are in development.
6. It is unlikely that a single drug or biological agent will meet the needs of all patients. Rather, the choice of the interventional agent that is used will depend on a range of factors that are related to the patient and to the particular cancer therapy they are receiving.

要点翻译：

1. 黏膜炎是抗肿瘤放疗和药物治疗的常见毒副作用，与多种不良症状、健康及经济后果相关。
2. 目前尚无有效方法预防或治疗黏膜炎。
3. 过去十年间，对黏膜炎病理生物学的认识快速深化。
4. 黏膜炎是一个涉及全黏膜动态交互事件的生物学复杂过程，最终靶向上皮干细胞。
5. 多种基于机制研究的抗黏膜炎药物正在研发中。
6. 单一药物或生物制剂不太可能满足所有患者的需求。干预剂的选择将取决于患者个体因素及其接受的特定癌症治疗方案等一系列相关因素。

英文摘要：

Oral and gastrointestinal mucositis is a toxicity of many forms of radiotherapy and chemotherapy. It has a significant impact on health, quality of life and economic outcomes that are associated with treatment. It also indirectly affects the success of antineoplastic therapy by limiting the ability of patients to tolerate optimal tumoricidal treatment. The complex pathogenesis of mucositis has only recently been appreciated and reflects the dynamic interactions of all of the cell and tissue types that comprise the epithelium and submucosa. The identification of the molecular events that lead to treatment-induced mucosal injury has provided targets for mechanistically based interventions to prevent and treat mucositis.

摘要翻译： 

口腔和胃肠道黏膜炎是多种放疗和化疗的一种毒性反应。它对健康、生活质量以及治疗相关的经济结果有显著影响。它还通过限制患者耐受最佳肿瘤杀伤治疗的能力，间接影响抗肿瘤治疗的成功。黏膜炎的复杂发病机制直到最近才被充分认识，它反映了构成上皮和黏膜下层的所有细胞和组织类型之间的动态相互作用。对导致治疗诱导的黏膜损伤的分子事件的识别，为基于机制的干预措施提供了靶点，以预防和治疗黏膜炎。

原文链接：

The pathobiology of mucositis