文章：

治疗转移性癌症：来自睾丸生殖细胞肿瘤的经验教训

Curing metastatic cancer: lessons from testicular germ-cell tumours

原文发布日期：2003-07-01

DOI: 10.1038/nrc1120

类型: Review Article

开放获取: 否

要点：

1. Metastatic testicular germ-cell tumours (TGCTs), in contrast to nearly all other cancers in adults, can be cured with drugs (cisplatin-based combination chemotherapy). But why are metastatic TGCTs so curable?
2. TGCT cells grown in the laboratory are 2–4 times more sensitive to cisplatin than most other types of cancer cell, so they provide a representative model system with which to study the mechanisms that control cisplatin sensitivity.
3. Testis tumour cells are deficient in one particular type of DNA repair — nucleotide excision repair — and consequently have a reduced capacity to repair the DNA damage caused by cisplatin.
4. Testis tumour cells are also defective in other aspects of DNA repair and are primed for apoptosis.
5. Targeting DNA-repair proteins might sensitize other types of cancer to cisplatin.

要点翻译：

1. 与成人中几乎所有其他癌症不同，转移性睾丸生殖细胞瘤可通过药物（以顺铂为基础的联合化疗）治愈。但为何转移性睾丸生殖细胞瘤如此可治愈？
2. 实验室中培养的睾丸生殖细胞瘤细胞对顺铂的敏感性是大多数其他类型癌细胞的2-4倍，因此它们为研究控制顺铂敏感性的机制提供了一个代表性模型系统。
3. 睾丸肿瘤细胞缺乏一种特定的DNA修复方式——核苷酸切除修复——因此修复顺铂引起的DNA损伤的能力降低。
4. 睾丸肿瘤细胞在DNA修复的其他方面也存在缺陷，并且易于凋亡。
5. 靶向DNA修复蛋白可能会提高其他类型癌症对顺铂的敏感性。

英文摘要：

Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.

摘要翻译： 

大多数转移性癌症是致命的。然而，超过80%的转移性睾丸生殖细胞瘤（TGCTs）患者可以通过顺铂联合化疗治愈。为什么TGCTs比其他大多数肿瘤类型对化疗更敏感？对这一问题的回答可能为转移性癌症带来新的治疗方法。

原文链接：

Curing metastatic cancer: lessons from testicular germ-cell tumours