文章：

基底膜：结构、组装及其在肿瘤血管生成中的作用

Basement membranes: structure, assembly and role in tumour angiogenesis

原文发布日期：2003-06-01

DOI: 10.1038/nrc1094

类型: Review Article

开放获取: 否

要点：

1. Vascular basement membranes (BMs) are important structural and functional components of all blood vessels/capillaries and have a crucial role in determining the progression of cancer.
2. Constituents of vascular BMs, such as type IV collagen, laminin, SPARC and perlecan, have emerged as key regulators of angiogenesis.
3. Type IV collagen and laminin can exert both positive and negative regulation of angiogenesis, depending on their structural integrity and assembly.
4. Cryptic domains of type IV collagen can be liberated by proteolytic enzymes, such as matrix metalloproteinases, to expose novel integrin binding sites and angiogenesis inhibitory sequences.
5. Arrestin, canstatin, tumstatin and endostatin are novel BM-derived endogenous inhibitors of angiogenesis.
6. Not all vascular BMs are the same, providing a novel tissue-specific regulation of endothelial-cell behaviour and possibly the rate of cancer progression in a given organ.

要点翻译：

1. 血管基底膜是所有血管/毛细血管的重要结构和功能组成部分，对癌症的进展具有决定性作用。
2. 血管基底膜的组成成分，如IV型胶原蛋白、层粘连蛋白、SPARC和基底膜蛋白聚糖，已成为血管生成的关键调节因子。
3. IV型胶原蛋白和层粘连蛋白可对血管生成产生正向或负向调节，具体取决于其结构完整性和组装方式。
4. IV型胶原蛋白的隐性结构域可通过蛋白酶（如基质金属蛋白酶）解离，从而暴露新的整合素结合位点和血管生成抑制序列。
5. Arrestin、Canstatin、Tumstatin和Endostatin是新型的基底膜源性内源性血管生成抑制剂。
6. 并非所有血管基底膜都相同，这种差异性为内皮细胞行为提供了新型组织特异性调节机制，并可能影响特定器官中癌症的进展速度。

英文摘要：

In recent years, the basement membrane (BM) — a specialized form of extracellular matrix (ECM) — has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.

摘要翻译： 

近年来，基底膜（BM）——一种特殊形式的细胞外基质（ECM）——已被认为是细胞行为的重要调节者，而不仅仅是组织的结构特征。基底膜介导组织分区，并向上皮细胞传递有关外部微环境的信号。基底膜也是血管的重要结构和功能组成部分，构成内皮细胞和周细胞的细胞外微环境传感器。血管基底膜成分最近被发现参与调节肿瘤血管生成，使其成为潜在癌症治疗的有吸引力的候选靶点。

原文链接：

Basement membranes: structure, assembly and role in tumour angiogenesis