Background/Objectives: Hypopigmented mycosis fungoides (hMF) is a rare variant of mycosis fungoides (MF) often seen in younger patients and individuals with darker skin phototypes. The lesions develop as hypopigmented patches or plaques, and they are usually asymptomatic and respond well to topical treatment or phototherapy.Methods: We provide a systematic review on hMF with onset at or beyond 30 years of age, based on SCOPUS, PubMed, and Embase databases. A total of 13 original articles, totaling 34 patients, were included in this review. Evidence was limited to case reports and small series; PROSPERO registration is CRD420251181894.Results: The majority of cases did not progress beyond stage IB and commonly used treatment methods, including topical corticosteroids and phototherapy. In three patients, a progression of the disease occurred, and in two of them it was fetal. Among patients receiving phototherapy, PUVA therapy achieved complete remission more often than UVB (13 out of 17 cases vs. 8 out of 16 cases). Although recurrences occurred with both treatments, they were less frequent, and relapses took longer to develop in the PUVA group.Conclusions: In this cohort, PUVA appeared to be associated with higher complete response rates and longer remission duration than UVB. However, this advantage of PUVA is derived from low-level evidence and should be confirmed in prospective comparative studies.
背景/目的：色素减退型蕈样肉芽肿（hMF）是蕈样肉芽肿（MF）的一种罕见亚型，常见于年轻患者及深色皮肤光型个体。皮损表现为色素减退斑片或斑块，通常无症状，对局部治疗或光疗反应良好。方法：基于SCOPUS、PubMed和Embase数据库，我们对30岁及以上发病的hMF进行了系统综述，共纳入13篇原始文献，涉及34例患者。证据仅限于病例报告和小规模病例系列；PROSPERO注册号为CRD420251181894。结果：多数病例未进展至IB期以上，常用治疗方法包括局部皮质类固醇和光疗。3例患者出现疾病进展，其中2例为致命性。在接受光疗的患者中，PUVA疗法比UVB疗法更易实现完全缓解（17例中13例 vs. 16例中8例）。尽管两种疗法均有复发，但PUVA组复发频率较低，且复发间隔时间更长。结论：在本队列中，与UVB相比，PUVA似乎与更高的完全缓解率和更长的缓解期相关。但PUVA的这一优势基于低级别证据，需在前瞻性比较研究中进一步验证。
肿瘤(癌症)患者之家