Background/Objective:Prostate cancer (PCa) is the leading cause of death in the ageing male population across the globe, and trace metals have garnered much attention due to their sometimes-dual role in cellular mechanisms, as such contribute to the development and progression of prostate cancer.Methods:This review consolidates the results of case-control studies that investigated the concentrations of certain trace metals—Arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), selenium (Se), and zinc (Zn) in various biological samples.Results:There are decreased concentrations of Se and Zn and increased Cd concentrations in samples of PCa patients when compared to healthy controls. As, Hg, Ni, and Pb concentrations have proven to be insignificant.Conclusions:There are other variables to consider and limitations that need to be investigated in studies of this nature; however, the results have been consistent in that increased exposure to toxic metals such as Cd, along with a deficiency in protective essential nutrients like Zn and Se, tends to produce a prostatic environment.
背景/目的：前列腺癌是全球老年男性群体中的主要死亡原因，微量元素因其在细胞机制中的双重作用备受关注，这些作用参与并影响了前列腺癌的发生与发展。
方法：本文综述了多项病例对照研究的结果，这些研究检测了不同生物样本中多种微量元素的浓度，包括砷（As）、镉（Cd）、汞（Hg）、锰（Mn）、镍（Ni）、铅（Pb）、硒（Se）和锌（Zn）。
结果：与健康对照相比，前列腺癌患者的样本中硒和锌的浓度降低，而镉的浓度升高。砷、汞、镍和铅的浓度未显示显著相关性。
结论：此类研究仍需考虑其他变量并探讨其局限性，但结果一致表明，有毒金属（如镉）暴露的增加以及保护性必需营养素（如锌和硒）的缺乏，往往共同构成了更易诱发前列腺癌的生理环境。
肿瘤(癌症)患者之家