Background/Objectives: Prostate cancer is the most frequent male malignancy. The incidence of disease varies among different ethnic groups. CYP3A polymorphisms are candidates for prostate cancer susceptibility studies. The aim of the present study is to investigate the ethnicity-related clinical impact ofCYP3A4variants on prostate cancer risk. Methods: A systematic literature search and meta-analysis were conducted according to PRISMA guidelines. A total of 10 eligible studies, including 3116 prostate cancer cases and 3008 healthy controls, were analyzed. We evaluated the association between theCYP3A4*1B(rs2740574, −392 A > G) variant and prostate cancer risk in European Caucasians. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using six genetic models. Data were analyzed using fixed and random-effects models based on the I2 value of heterogeneity magnitude. Funnel plots and Egger’s linear regression tests were used to assess publication bias. Results:CYP3A4*1Bwas associated with prostate cancer susceptibility in the allele (G vs. A: OR = 1.32, CI = 0.91–1.93), dominant (AG + GG vs. AA OR = 1.41, CI = 0.95–2.09), recessive (GG vs. AA + AG, OR = 1.82, CI = 1.26–2.63), homozygous (GG vs. AA, OR = 1.92, CI = 1.32–2.77), heterozygous model (AG vs. AA, OR = 1.31, CI = 0.89–1.93) and co-dominant model (AG vs. AA + GG; OR = 1.27, CI = 0.88–1.85). Significant heterogeneity characterized the allele, as well as the dominant model (I2 = 84.1%, I2 = 80.0%). Egger’s tests (p< 0.05) and funnel plots did not identify publication bias. Conclusions: The present meta-analysis indicates that the G allele and GG genotype might affect prostate cancer susceptibility in European Caucasians; however, the validity and reliability of the results need to be examined in future research.
背景/目的：前列腺癌是最常见的男性恶性肿瘤，其发病率在不同种族群体中存在差异。CYP3A基因多态性是前列腺癌易感性研究的候选因素。本研究旨在探讨CYP3A4基因变异对前列腺癌风险的种族相关性临床影响。方法：依据PRISMA指南进行系统性文献检索与荟萃分析。共纳入10项符合条件的研究，包含3116例前列腺癌患者及3008例健康对照。我们评估了欧洲白种人中CYP3A4*1B（rs2740574，-392 A>G）变异与前列腺癌风险的关联性，采用六种遗传模型计算合并比值比（OR）及其95%置信区间（CI）。根据异质性I²值选用固定效应或随机效应模型进行数据分析，并通过漏斗图与Egger线性回归检验评估发表偏倚。结果：CYP3A4*1B在等位基因（G vs. A：OR=1.32，CI=0.91-1.93）、显性（AG+GG vs. AA OR=1.41，CI=0.95-2.09）、隐性（GG vs. AA+AG，OR=1.82，CI=1.26-2.63）、纯合子（GG vs. AA，OR=1.92，CI=1.32-2.77）、杂合子（AG vs. AA，OR=1.31，CI=0.89-1.93）及共显性模型（AG vs. AA+GG；OR=1.27，CI=0.88-1.85）中均显示与前列腺癌易感性相关。等位基因与显性模型存在显著异质性（I²=84.1%，I²=80.0%）。Egger检验（p<0.05）与漏斗图未发现发表偏倚。结论：本荟萃分析表明G等位基因与GG基因型可能影响欧洲白种人的前列腺癌易感性，但结果的效度与信度需在未来研究中进一步验证。
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