Clear cell renal cell carcinoma is the most common histological type of renal cancer, which is a common cancer type usually associated with a long clinical course. During this course, various metastatic sites can be observed. In this review, we have focused on metastases to the thyroid gland. We conducted research in three medical databases, including PubMed, Scopus, and Web of Science, using the same search algorithm. Our inclusion criteria focused on case reports and case series studies since 2011, covering therapeutic strategies for the primary and/or metastatic disease, as well as subsequent follow-up data. Studies with insufficient or uncertain data, or written in a language other than English, were excluded. An analysis of 510 articles from PubMed, 1729 from Scopus, and 649 from Web of Science, after application of inclusion and exclusion criteria, resulted in 77 reports, analyzing 189 patients. A description of the clinical, pathological, ancillary, and follow-up data, in the light of recent therapeutic schemes, was attempted. Our results suggest that metastases’ imaging features comprised more commonly a solitary nodule with a median size of 3.5 cm and worrisome features in ultrasonography, such as heterogeneity, hypoechogenicity, partially solid configuration, and variable internal vascularization. Histological and immunohistochemical examination of the lesion is necessary because these findings are not specific. Common non-thyroid metastases are seen in the urogenital system, lungs, and pancreas. We calculated the restricted mean survival from primary diagnosis at 274.6 months (95% CI: 264.3–285.0 months) and the restricted mean survival from thyroid metastases treatment at 93.9 months (95% CI: 65.3–122.4 months). Results regarding how patient characteristics affect these survival numbers were statistically nonsignificant (p> 0.05).
透明细胞肾细胞癌是最常见的肾癌组织学类型，这是一种通常具有较长临床病程的常见癌症类型。在此病程中，可观察到多种转移部位。本综述聚焦于甲状腺转移病例。我们采用相同检索算法在PubMed、Scopus和Web of Science三个医学数据库中进行检索。纳入标准限定为2011年以来的病例报告和病例系列研究，涵盖原发性和/或转移性疾病的治疗策略及后续随访数据。排除数据不足或不确定、非英文撰写的文献。经纳入排除标准筛选后，共分析PubMed数据库510篇、Scopus数据库1729篇、Web of Science数据库649篇文献，最终纳入77篇报告，涉及189例患者。我们结合最新治疗方案对临床、病理学、辅助检查及随访数据进行了系统性描述。研究结果显示：转移灶影像学特征多表现为单发结节（中位直径3.5厘米），超声检查可见可疑特征，包括异质性、低回声、部分实性结构及多变性内部血管形成。由于这些表现缺乏特异性，必须进行病灶组织学和免疫组化检查。常见非甲状腺转移部位包括泌尿生殖系统、肺部和胰腺。经计算，原发性诊断后的限制平均生存期为274.6个月（95% CI：264.3-285.0个月），甲状腺转移治疗后的限制平均生存期为93.9个月（95% CI：65.3-122.4个月）。患者特征对生存期影响的统计学分析结果均未达到显著水平（p>0.05）。
Clear Cell Renal Cell Carcinoma Metastasis to the Thyroid: A Narrative Review of the Literature
肿瘤(癌症)患者之家