文章：

中心性肥胖、肥胖、代谢综合征与≥75岁成人甲状腺癌风险：一项韩国全国性队列研究

Central Adiposity, Obesity, Metabolic Syndrome, and the Risk of Thyroid Cancer in Adults Aged ≥75 Years: A Nationwide Korean Cohort Study

原文发布日期：24 December 2025

DOI: 10.3390/cancers18010049

类型: Article

开放获取: 是

英文摘要：

Background: The contribution of adiposity and metabolic syndrome (MetS) to thyroid cancer risk in late life, particularly among the elderly, is unclear.Methods: We conducted a nationwide cohort study of Korean adults aged ≥75 years who underwent standardized health screening. Exposures were body mass index (BMI), waist circumference (WC), and MetS defined by standard clinical criteria. The incidence of thyroid cancer was determined using administrative data. Fine–Gray sub-distribution hazard models estimated adjusted hazard ratios (HRs) with prespecified stratification by sex and age (75–84 vs. ≥85 years).Results: Among 1,164,707 participants (60.3% women), 2645 incident cases were identified. In the fully adjusted models, obesity (BMI ≥ 25 kg/m2) was associated with a 37% higher hazard (HR, 1.37; 95% confidence interval [CI], 1.27–1.49) and MetS with an 18% higher hazard (HR, 1.18; 95% CI, 1.09–1.28). In sex-stratified models, MetS was associated with thyroid cancer in women (HR 1.19; 95% CI, 1.08–1.31) and showed a similar direction of association in men (HR 1.16; 95% CI, 1.00–1.35), with overlapping CIs. By age, associations were evident at 75–84 years (MetS: HR, 1.18; obesity: HR, 1.36), whereas at ≥85 years, only obesity remained significant (HR, 1.90; 95% CI, 1.13–3.18). Among MetS components, high WC showed the most consistent association (HR, 1.31; 95% CI, 1.21–1.42).Conclusions: In adults aged ≥75 years, general obesity and, in particular, central adiposity are robustly associated with incident thyroid cancer, whereas metabolic syndrome confers a more modest and mainly age- and sex-specific additional risk.

摘要翻译： 

背景：肥胖与代谢综合征（MetS）对晚年特别是老年人群甲状腺癌风险的影响尚不明确。 方法：本研究对韩国年龄≥75岁且接受标准化健康筛查的成年人开展全国性队列研究。暴露因素包括体重指数（BMI）、腰围（WC）以及依据临床标准定义的MetS。甲状腺癌发病率通过行政数据确定。采用Fine-Gray亚分布风险模型计算校正风险比（HR），并按性别和年龄（75-84岁 vs. ≥85岁）进行预设分层分析。 结果：在1,164,707名参与者（女性占60.3%）中，共发现2645例新发甲状腺癌病例。在完全校正模型中，肥胖（BMI ≥ 25 kg/m²）与甲状腺癌风险升高37%相关（HR 1.37；95%置信区间[CI] 1.27–1.49），MetS与风险升高18%相关（HR 1.18；95% CI 1.09–1.28）。性别分层分析显示，MetS与女性甲状腺癌风险相关（HR 1.19；95% CI 1.08–1.31），在男性中也呈现相似关联趋势（HR 1.16；95% CI 1.00–1.35），其置信区间存在重叠。按年龄分层，75-84岁人群中关联显著（MetS：HR 1.18；肥胖：HR 1.36），而在≥85岁人群中仅肥胖仍具显著关联（HR 1.90；95% CI 1.13–3.18）。在MetS组分中，高腰围显示出最一致的关联性（HR 1.31；95% CI 1.21–1.42）。 结论：在≥75岁的成年人中，全身性肥胖（尤其是中心性肥胖）与甲状腺癌发病风险显著相关，而代谢综合征带来的额外风险相对有限，且主要表现出年龄与性别特异性。

原文链接：

Central Adiposity, Obesity, Metabolic Syndrome, and the Risk of Thyroid Cancer in Adults Aged ≥75 Years: A Nationwide Korean Cohort Study