Background and Objectives: Accurate endoscopic lesion localization is crucial for planning and performing curative-intent surgery in colorectal cancer management. The use of indocyanine green (ICG) has been described as a novel alternative for colorectal lesion marking. Materials and Methods: We have performed a systematic review of the literature on the use of ICG-based tattooing for patients with colorectal cancer undergoing surgery. Results: A total of 19 studies were identified. Seven studies reposted the rates of successful intraoperative localization following ICG tattooing. Additionally, six studies provided detailed descriptions of the administration protocols, including both timing and dosage. A total of twelve studies described the utility of ICG-based tattooing for subsequent lymphadenectomy and its oncologic implications. Lymphadenectomy under fluorescent guidance was associated with increased lymph node yields as well as a change to the surgical lymphadenectomy plan in a significant proportion of patients. Conclusions: ICG-based endoscopic tattooing has demonstrated significant value in facilitating precise lesion localization during curative-intent colorectal surgery. Moreover, its use has been extended to guiding lymphadenectomy, with reports indicating improved lymph node yields. Nevertheless, further research is required to standardize protocols and address existing limitations.
背景与目的：在结直肠癌治疗中，精确的内镜下病灶定位对于规划和实施根治性手术至关重要。吲哚菁绿（ICG）的应用已被描述为结直肠病变标记的新型替代方法。材料与方法：我们对接受手术治疗的结直肠癌患者使用ICG标记技术的相关文献进行了系统性综述。结果：共纳入19项研究。其中7项研究报告了ICG标记后术中定位成功率；另有6项研究详细描述了给药方案，包括注射时机与剂量。总计12项研究阐述了ICG标记技术对后续淋巴结清扫术的辅助价值及其肿瘤学意义。荧光引导下的淋巴结清扫术不仅提高了淋巴结检出数量，还在相当比例的患者中改变了既定的淋巴结清扫方案。结论：基于ICG的内镜下标记技术在根治性结直肠癌手术中展现出促进病灶精确定位的重要价值。此外，该技术已扩展应用于淋巴结清扫引导，现有报告表明其能提高淋巴结检出率。然而，仍需进一步研究以规范操作方案并解决现有局限性。
肿瘤(癌症)患者之家