Background/Objectives:Obesity is a common comorbidity but there remains limited understanding on how higher obesity rates in rural areas may impact physical function decline and other health domains among cancer patients. This study addresses this gap by examining the association between body mass index (BMI) and physical function among a cohort of rural advanced cancer patients.Methods:This cross-sectional analysis uses baseline data from the Nurse AMIE trial (NCT04673019). Individuals were categorized as ‘normal weight’ (BMI ≤ 25 kg/m2), ‘overweight’ (BMI > 25 to 30 kg/m2), and ‘obese’ (BMI > 30 kg/m2). Objective physical function was measured by the Short Physical Performance Battery (SPPB) and subjective physical function and health domains were measured using surveys (PROMIS; SF-36).Results:Of 348 patients included, 88 (25.3%) were classified as ‘normal weight’, 107 (30.7%) as ‘overweight’, and 153 (44.0%) as ‘obese’. Average age was 64.8 years (SD = 12.2), 46% (n = 160) were female, 95% were white (n = 331), and 52% (n = 182) were Stage 4. Total SPPB scores revealed poorer functioning with higher BMI (M ± SD: BMI ≤ 25 kg/m2: 9.1 ± 2.3; BMI > 25–30 kg/m2: 8.3 ± 3.1; BMI > 30 kg/m2: 8.1 ± 2.8;p= 0.04). Similarly, scores from the SF-36 revealed subjective physical function was lower with higher BMI (BMI ≤ 25 kg/m2: 57.9 ± 29.1; BMI > 25–30 kg/m2: 53.7 ± 28.0; BMI > 30 kg/m2: 47.6 ± 27.6;p= 0.004). Participants reported lower levels of energy and greater fatigue with higher BMI (BMI ≤ 25 kg/m2: 49.8 ± 26.1; BMI > 25–30 kg/m2: 45.1 ± 24.6; BMI > 30 kg/m2: 40.7 ± 22.6;p= 0.01).Conclusions:Higher BMI is associated with poorer physical function and increased fatigue among rural advanced cancer patients, highlighting the need for supportive care related to physical function in this at-risk group.
**背景/目的：** 肥胖是常见的共病，但目前对于农村地区较高的肥胖率如何影响癌症患者身体功能衰退及其他健康领域仍知之甚少。本研究通过探讨农村晚期癌症患者队列中体重指数（BMI）与身体功能之间的关联，以填补这一知识空白。 **方法：** 本横断面分析采用“护士AMIE试验”（NCT04673019）的基线数据。研究对象被分为“正常体重”（BMI ≤ 25 kg/m²）、“超重”（BMI > 25至30 kg/m²）和“肥胖”（BMI > 30 kg/m²）三组。客观身体功能通过简易体能状况量表（SPPB）评估，主观身体功能及其他健康领域则通过问卷调查（PROMIS；SF-36）进行测量。 **结果：** 在纳入的348例患者中，88例（25.3%）为“正常体重”，107例（30.7%）为“超重”，153例（44.0%）为“肥胖”。平均年龄为64.8岁（标准差=12.2），46%（n=160）为女性，95%（n=331）为白人，52%（n=182）处于癌症第4期。SPPB总分显示，BMI越高，身体功能越差（均值±标准差：BMI ≤ 25 kg/m²：9.1±2.3；BMI > 25–30 kg/m²：8.3±3.1；BMI > 30 kg/m²：8.1±2.8；p=0.04）。同样，SF-36评分显示，主观身体功能随BMI升高而降低（BMI ≤ 25 kg/m²：57.9±29.1；BMI > 25–30 kg/m²：53.7±28.0；BMI > 30 kg/m²：47.6±27.6；p=0.004）。参与者报告显示，BMI越高，精力水平越低，疲劳感越强（BMI ≤ 25 kg/m²：49.8±26.1；BMI > 25–30 kg/m²：45.1±24.6；BMI > 30 kg/m²：40.7±22.6；p=0.01）。 **结论：** 在农村晚期癌症患者中，较高的BMI与较差的身体功能和更强的疲劳感相关，这凸显了针对这一高危群体开展身体功能相关支持性护理的必要性。
肿瘤(癌症)患者之家