Non-coding RNA (ncRNA) encompasses a large family of molecules that are crucial regulators of gene expression. This family includes microRNA, piwi-interacting RNA, and long non-coding RNA (lncRNA); each class is associated with different mechanisms of action that influence gene expression. Based on the available evidence, these molecules have important roles in physiological and pathological processes. For example, ncRNAs are strongly implicated in oncogenesis by mediating the expression of tumour suppressors and oncogenes. This review comprehensively describes the latest findings regarding the roles of lncRNAs in the pathophysiology of melanoma. Key aspects of melanoma biology and various mechanisms regulated by lncRNAs are discussed. Furthermore, future areas exploring potential biomarkers and therapeutic targets are presented.
非编码RNA（ncRNA）是一大类对基因表达具有关键调控作用的分子家族，主要包括微小RNA、piwi相互作用RNA以及长链非编码RNA（lncRNA）。各类非编码RNA通过不同的作用机制参与基因表达的调控。现有研究表明，这些分子在生理和病理过程中发挥着重要作用，例如通过调控抑癌基因和癌基因的表达，非编码RNA与肿瘤发生发展密切相关。本综述系统阐述了lncRNA在黑色素瘤病理生理过程中的最新研究进展，重点探讨了黑色素瘤生物学特性及lncRNA参与调控的多种分子机制，并对未来可能作为生物标志物和治疗靶点的研究方向进行了展望。
Silent Players, Loud Impact: The Influence of lncRNAs on Melanoma Progression
肿瘤(癌症)患者之家