Background: Appendiceal neoplasms are rare, but recent data indicate a rising trend, particularly in patients under the age of 50. These tumours are often diagnosed incidentally during histopathological examination. This study has aimed to examine the incidence and histological subtypes of appendiceal neoplasms in a Southern Hungarian population. Methods: Our study included neoplastic appendix specimens processed at the University of Szeged between 2014 and 2023. Results: Neoplasms were identified in 71 cases from 3640 appendectomies (1.9%). Benign lesions were present in 37% of cases (n= 26), with the most common subtype being the sessile serrated lesion (n= 20). Mucinous and malignant neoplasms were found in 63% of cases (n= 45), most frequently low-grade appendiceal mucinous neoplasm (n= 19), followed by neuroendocrine tumour (n= 17). Notably, colorectal neoplasm was identified in 50% of benign, and 42.2% of mucinous and malignant cases during a mean follow-up of 33.4 months. Significant associations were found between histological subtype and age (p= 0.022), complete resection (p= 0.012), presence of vascular invasion (p= 0.007), and localisation of potentially associated colorectal carcinoma (p= 0.018). Additionally, tumour dignity showed significant correlations with tumour, node, metastasis (TNM) stage (p< 0.001), vascular invasion (p= 0.017), and lastly, occurrence (p= 0.031) and localisation (p= 0.003) of associated colorectal carcinoma. Conclusions: The prevalence and characteristics observed in this Southern Hungarian population were consistent with international data, although raw case numbers suggested an upward trend. The high rate of associated colorectal neoplasms underscores the importance of thorough pathological evaluation and long-term surveillance.
背景：阑尾肿瘤较为罕见，但近期数据显示其发病率呈上升趋势，尤其在50岁以下人群中。这类肿瘤常在组织病理学检查中被偶然发现。本研究旨在探讨匈牙利南部人群中阑尾肿瘤的发病率及组织学亚型分布。 方法：本研究纳入了2014年至2023年间塞格德大学病理科处理的阑尾肿瘤标本。 结果：在3640例阑尾切除标本中，共发现71例肿瘤性病变（占比1.9%）。其中良性病变占37%（26例），最常见的亚型为无蒂锯齿状病变（20例）。黏液性及恶性肿瘤占63%（45例），以低级别阑尾黏液性肿瘤最为常见（19例），其次为神经内分泌肿瘤（17例）。在平均33.4个月的随访期间，50%的良性病例及42.2%的黏液性/恶性病例同时被检出结直肠肿瘤。组织学亚型与患者年龄（p=0.022）、手术完整切除率（p=0.012）、血管侵犯情况（p=0.007）以及潜在相关结直肠癌的定位（p=0.018）存在显著相关性。此外，肿瘤性质与TNM分期（p<0.001）、血管侵犯（p=0.017），以及相关结直肠癌的发生率（p=0.031）和定位（p=0.003）均呈现显著关联。 结论：尽管原始病例数显示上升趋势，但匈牙利南部人群的阑尾肿瘤患病率与特征与国际数据基本一致。较高的伴发结直肠肿瘤率凸显了全面病理评估与长期随访监测的重要性。
Examination of Appendiceal Neoplasms—A Retrospective, Single-Centre, Cohort Study
肿瘤(癌症)患者之家