Background: Adolescent cancer survivors constitute a clinically vulnerable population whose psychosocial adjustment following oncological treatment remains insufficiently characterized, particularly within Central and Eastern Europe. The present study aimed to evaluate health-related quality of life (HRQoL) and depressive symptomatology among Polish adolescent survivors, identify their psychological predictors, and determine age-related differences in these associations. Methods: A cross-sectional study was conducted among 165 survivors aged 11–18 years, recruited from four pediatric oncology centers. Participants completed the KIDSCREEN-10 (HRQoL) and the Children’s Depression Inventory-2™ (CDI-2™). Descriptive statistics, Spearman rank-order correlations, and multiple regression analyses were performed separately for younger (primary school) and older (secondary school) cohorts. Results: The findings demonstrated a pronounced polarization of HRQoL, with approximately one-third of participants (32.7%) scoring within the clinically low range. Depressive symptoms were prevalent, particularly in the domains of Negative Mood (M = 19.93) and Ineffectiveness (M = 15.45), while Negative Self-Esteem levels were comparatively low (M = 8.02). HRQoL correlated strongly and inversely with Interpersonal Problems (rs = −0.89,p< 0.001). Regression analyses indicated that Negative Self-Esteem (CDI-2D) was the strongest negative predictor of HRQoL in both age groups, whereas Ineffectiveness (CDI-2C) and Negative Mood (CDI-2A) emerged as significant positive predictors. Interpersonal Problems (CDI-2B) were predictive only in older adolescents, suggesting a developmental shift in determinants of well-being. Conclusions: Adolescent cancer survivors exhibit a distinctive psychological pattern characterized by pronounced emotional distress without pervasive self-devaluation. HRQoL appears highly polarized and primarily determined by self-esteem and interpersonal functioning. These findings underscore the necessity of developmentally tailored psychosocial interventions addressing self-worth, peer reintegration, and socio-economic stressors in survivorship care.
背景：青少年癌症幸存者是一个临床易感群体，其肿瘤治疗后的心理社会适应状况尚未得到充分描述，尤其是在中欧和东欧地区。本研究旨在评估波兰青少年幸存者的健康相关生活质量（HRQoL）和抑郁症状，识别其心理预测因素，并确定这些关联中与年龄相关的差异。 方法：本研究为横断面研究，从四家儿科肿瘤中心招募了165名年龄在11至18岁之间的幸存者。参与者完成了KIDSCREEN-10（HRQoL）和儿童抑郁量表第二版™（CDI-2™）。对较年轻（小学）和较年长（中学）队列分别进行了描述性统计、斯皮尔曼等级相关分析和多元回归分析。 结果：研究结果显示，健康相关生活质量呈现明显的两极分化，约三分之一（32.7%）的参与者得分处于临床低值范围。抑郁症状普遍存在，尤其在负面情绪（M = 19.93）和无效感（M = 15.45）领域，而负面自尊水平相对较低（M = 8.02）。健康相关生活质量与人际问题呈强烈的负相关（rs = -0.89, p < 0.001）。回归分析表明，负面自尊（CDI-2D）是两个年龄组中健康相关生活质量最强的负面预测因子，而无效感（CDI-2C）和负面情绪（CDI-2A）则是显著的正向预测因子。人际问题（CDI-2B）仅在年长青少年中具有预测性，这表明幸福感决定因素存在发展性转变。 结论：青少年癌症幸存者表现出一种独特的心理模式，其特征是显著的情绪困扰，但没有普遍的自贬倾向。健康相关生活质量呈现高度两极分化，主要由自尊和人际功能决定。这些发现强调了在幸存者护理中，有必要提供针对发展阶段的心理社会干预措施，以解决自我价值、同伴再融入和社会经济压力源等问题。
肿瘤(癌症)患者之家