文章：

“代谢不稳定性”作为子宫内膜癌发病机制中新风险标准的作用

The Role of “Metabolic Instability” as a New Risk Criterion in the Pathogenesis of Endometrial Cancer

原文发布日期：29 November 2025

DOI: 10.3390/cancers17233840

类型: Article

开放获取: 是

英文摘要：

Background: Metabolic instability, encompassing fluctuations in body weight, glucose, insulin, and sex hormones, may create a pro-inflammatory and proliferative endometrial microenvironment even in women with normal BMI.Methods: A systematic literature review was performed in PubMed, Embase, and Google Scholar, including studies assessing the relationship between metabolic, endocrine, and inflammatory factors and the risk of endometrial cancer in non-obese women.Results: Variability in body weight and hormonal parameters was associated with chronic subclinical inflammation, altered leptin/adiponectin secretion, decreased sex hormone-binding globulin, and increased estrogen bioavailability. These changes disrupt the homeostatic rhythm of endometrial cell regeneration and increase the likelihood of neoplastic transformation.Conclusions: Metabolic instability represents a novel integrated risk factor for endometrial cancer among women without obesity and should be incorporated into future risk stratification and prevention models.

摘要翻译： 

背景：代谢不稳定性，包括体重、血糖、胰岛素和性激素的波动，即使在体重指数正常的女性中，也可能导致子宫内膜微环境呈现促炎和增殖状态。 方法：在PubMed、Embase和Google Scholar数据库中进行系统性文献回顾，纳入评估非肥胖女性代谢、内分泌及炎症因子与子宫内膜癌风险关系的研究。 结果：体重和激素参数的波动与慢性亚临床炎症、瘦素/脂联素分泌改变、性激素结合球蛋白降低以及雌激素生物利用度增加相关。这些变化破坏了子宫内膜细胞再生的稳态节律，增加了肿瘤转化的可能性。 结论：代谢不稳定性是非肥胖女性子宫内膜癌的一种新型综合风险因素，应纳入未来的风险分层和预防模型中。

原文链接：

The Role of “Metabolic Instability” as a New Risk Criterion in the Pathogenesis of Endometrial Cancer