文章：

非对比增强磁共振T2加权成像在检测脑膜瘤生长方面与对比增强T1加权成像具有同等准确性。

Non-Contrast MR T2-Weighted Imaging Is as Accurate as Contrast-Enhanced T1-Weighted Imaging in the Detection of Meningioma Growth

原文发布日期：27 November 2025

DOI: 10.3390/cancers17233800

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Asymptomatic meningiomas require frequent follow-up using MR imaging, with the standard of care being contrast-enhanced T1-weighted imaging (CE-T1WI) with Gadolinium-Based Contrast Agents (GBCAs). Limiting GBCA exposure reduces the environmental impact and limits possible gadolinium deposition in the brain. Therefore, the research objective was investigating the diagnostic accuracy of T2WI for evaluating significant meningioma growth (≥10% per year), using the CE-T1WI as reference standard.Methods: A total of 99 asymptomatic patients with the radiological diagnosis of meningioma and a minimum follow-up period of 11 months were retrospectively identified. Patients were scanned with various scanners in multiple hospitals. The maximum tumor diameter was measured in the transverse plane. Tumor growth was calculated in changes in millimeters and converted to percentages in the longest tumor diameter in the transverse plane. A paired-samplet-test was used to compare tumor growth on T2WI to CE-T1WI. The diagnostic accuracy of T2WI was determined by calculation of sensitivity, specificity, and positive and negative predictive values.Results: Mean follow-up time was 1.9 years. Significant tumor growth was found in 16 patients using T2WI, compared to 10 patients using CE-T1WI, which was not statistically significant. T2WI had a sensitivity of 80%, specificity of 90%, a positive predictive value of 47%, and negative predictive value of 98% for prediction of significant meningioma growth.Conclusions: T2WI was not inferior to CE-T1WI in the detection of significant tumor growth in asymptomatic meningioma and therefore can be used in follow-up to reduce gadolinium exposure.

摘要翻译： 

背景/目的：无症状脑膜瘤需频繁进行磁共振成像随访，标准方案是使用钆基对比剂（GBCAs）的对比增强T1加权成像（CE-T1WI）。限制GBCA暴露可降低环境影响并减少钆在脑内沉积的可能性。因此，本研究旨在以CE-T1WI为参考标准，探讨T2加权成像（T2WI）评估脑膜瘤显著生长（年增长率≥10%）的诊断准确性。 方法：回顾性纳入99例经影像学诊断为无症状脑膜瘤且随访时间至少11个月的患者。患者在多家医院使用不同扫描设备进行检查。在横断面图像上测量肿瘤最大直径，通过测量毫米级变化计算肿瘤生长情况，并转换为横断面最长肿瘤直径的百分比增长率。采用配对样本t检验比较T2WI与CE-T1WI的肿瘤生长测量结果。通过计算敏感性、特异性、阳性预测值和阴性预测值确定T2WI的诊断准确性。 结果：平均随访时间为1.9年。T2WI检测到16例患者出现显著肿瘤生长，而CE-T1WI检测到10例，两者差异无统计学意义。T2WI预测脑膜瘤显著生长的敏感性为80%，特异性为90%，阳性预测值为47%，阴性预测值为98%。 结论：在检测无症状脑膜瘤显著生长方面，T2WI不劣于CE-T1WI，因此可用于随访检查以减少钆暴露。

原文链接：

Non-Contrast MR T2-Weighted Imaging Is as Accurate as Contrast-Enhanced T1-Weighted Imaging in the Detection of Meningioma Growth