Background: Gastric cancer is the fifth most prevalent cancer diagnosed worldwide, and approximately 40% of patients who experience recurrence within five years develop hematogenous metastasis. Given that early prediction of recurrence may improve overall survival, there is a need for a biomarker that allows for repeated measurements and can accurately predict cancer stage. This study aimed to evaluate the potential of glucose-6-phosphate dehydrogenase activity, which is a factor associated with cancer progression, as a biomarker for predicting the stage of gastric cancer.Methods: This cross-sectional study retrospectively analyzed the medical records of patients with gastric cancer. Patients were classified into early-stage (Stage I–II) and advanced-stage (Stage III–IV) groups, and serum G6PD activity was compared between the two groups. Receiver operating characteristic (ROC) curve analysis was conducted to calculate the area under the curve (AUC), identifying the optimal cutoff value, and to determine the corresponding sensitivity and specificity.Results: Serum G6PD activity was significantly higher in the advanced-stage group compared to the early-stage group. Moreover, ROC curve analysis yielded an AUC of 0.70, indicating fair diagnostic performance. The optimal G6PD cutoff point was determined to be 12.05 U/g Hb, corresponding to a sensitivity of 0.59 and a specificity of 0.78.Conclusions: This study demonstrated the clinical utility of serum G6PD activity in predicting the stage of gastric cancer. As the test requires only a single drop of blood and provides rapid results, the test could be a practical tool for monitoring of recurrence in gastric cancer follow-up settings.
背景：胃癌是全球第五大常见癌症，约40%的患者在五年内复发并发生血行转移。鉴于早期预测复发可能提高总体生存率，需要一种能够重复测量并准确预测癌症分期的生物标志物。本研究旨在评估葡萄糖-6-磷酸脱氢酶活性作为预测胃癌分期生物标志物的潜力，该酶活性与癌症进展相关。 方法：本横断面研究回顾性分析了胃癌患者的医疗记录。将患者分为早期（I-II期）和晚期（III-IV期）两组，比较两组间血清G6PD活性。通过受试者工作特征曲线分析计算曲线下面积，确定最佳截断值，并计算相应的敏感性和特异性。 结果：晚期组血清G6PD活性显著高于早期组。ROC曲线分析显示AUC为0.70，表明其具有中等诊断效能。最佳G6PD截断值为12.05 U/g Hb，对应的敏感性为0.59，特异性为0.78。 结论：本研究证实了血清G6PD活性在预测胃癌分期中的临床价值。该检测仅需一滴血且能快速获得结果，可作为胃癌随访中监测复发的实用工具。
Serum Glucose-6-Phosphate Dehydrogenase Activity as a Biomarker for Gastric Cancer Stage Prediction
肿瘤(癌症)患者之家