文章：

多参数磁共振成像标记物与致密乳腺女性乳腺癌风险的相关性研究

Multiparametric MRI Markers Associated with Breast Cancer Risk in Women with Dense Breasts

原文发布日期：26 November 2025

DOI: 10.3390/cancers17233771

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: This study explored the associations of normal breast tissue characteristics on multiparametric MRI with clinical assessments of breast cancer risk in women with dense breasts.Methods: Women with dense breasts who underwent multiparametric MRI were included. Breast cancer risk was determined based on Tyrer–Cuzick (TC) lifetime risk scores, categorized as high (TC ≥ 20%) or low risk. Qualitative background parenchymal enhancement (BPE) assessment was obtained from imaging reports. Quantitative imaging markers were calculated, including median BPE, median apparent diffusion coefficient, and volume measures of the whole breast, fibroglandular tissue (FGT), blood vessels, and BPE regions. The associations between imaging markers and TC risk groups were evaluated using age-adjusted logistic regression and summarized by area under the receiver operating characteristic curve (AUC).Results: Seventy-seven women were evaluated; a total of 20 (26%) were low risk, and 57 (74%) were high risk. After adjusting for age and multiple testing, BPE:breast ratio (adj.p= 0.037), FGT:breast ratio (adj.p= 0.046), and BPE:vessel ratio (adj.p= 0.037) were positively associated with risk, while qualitative BPE was not (adj.p= 0.11). Overall, risk categorizations based on imaging markers were concordant with TC score in up to 70% of women.Conclusions: In women with dense breasts, quantitative measures from multiparametric MRI (BPE:breast, FGT:breast, and BPE:vessel ratios) moderately discriminated high- and low-risk groups, warranting further investigation of their value to supplement conventional breast cancer risk assessment tools.

摘要翻译： 

背景/目的：本研究探讨了致密乳腺女性中，多参数磁共振成像显示的正常乳腺组织特征与临床乳腺癌风险评估之间的关联。方法：纳入接受多参数磁共振成像检查的致密乳腺女性。乳腺癌风险依据Tyrer-Cuzick（TC）终身风险评分确定，分为高风险（TC ≥ 20%）和低风险组。从影像报告中获取定性背景实质强化（BPE）评估结果。计算定量影像标志物，包括BPE中位值、表观扩散系数中位值，以及全乳、纤维腺体组织、血管和BPE区域的体积测量值。采用年龄校正逻辑回归评估影像标志物与TC风险分组的关联性，并通过受试者工作特征曲线下面积（AUC）进行总结。结果：共评估77名女性，其中低风险20名（26%），高风险57名（74%）。经年龄校正和多重检验后，BPE:乳腺比值（校正p=0.037）、纤维腺体组织:乳腺比值（校正p=0.046）和BPE:血管比值（校正p=0.037）与风险呈正相关，而定性BPE无显著关联（校正p=0.11）。总体而言，基于影像标志物的风险分类与TC评分在高达70%的女性中具有一致性。结论：在致密乳腺女性中，多参数磁共振成像的定量测量指标（BPE:乳腺、纤维腺体组织:乳腺和BPE:血管比值）对高风险和低风险群体具有中等区分能力，值得进一步研究其作为传统乳腺癌风险评估工具补充手段的价值。

原文链接：

Multiparametric MRI Markers Associated with Breast Cancer Risk in Women with Dense Breasts