Background: Kaposi sarcoma (KS) is a human herpesvirus-8-associated vascular malignancy with four subtypes. Although several local therapies are available for cutaneous lesions, no standard treatment exists. Laser therapy is a minimally invasive treatment option; however, its efficacy and safety remain unclear. Objectives: To systematically review and analyze the available literature on the efficacy and safety of laser-based treatment protocols for cutaneous KS lesions. Methods: A comprehensive literature search was conducted up to August 2025 to identify randomized controlled trials, observational studies, and case series with ≥3 patients who received laser therapy for cutaneous KS. Data on patient and disease characteristics, laser protocols, outcomes and adverse events were extracted from the included studies. Results: Eight studies involving 79 patients with 371 treated lesions were included in this systematic review. The reported outcome rates varied greatly between different modalities, with inconsistent outcome definitions. No recurrence was reported in seven studies, whereas the condition in all cases in the eighth study recurred. Overall, laser therapy was well tolerated with minimal adverse effects, including mild atrophic scarring, transient post-inflammatory changes, and hyperpigmentation. Six studies were eligible for meta-analysis, yielding a pooled significant response rate of 88% (95% CI: 44.1–98.6%,I2= 86.3%). Conclusions: Available data indicate that laser therapy may represent a safe and effective option for cutaneous KS, particularly Nd:YAG, which demonstrated good efficacy with low recurrence rates; however, further research is required to define its efficacy more precisely and to standardize treatment protocols.
背景：卡波西肉瘤（KS）是一种与人疱疹病毒8型相关的血管性恶性肿瘤，分为四种亚型。尽管针对皮肤病变已有多种局部治疗方法，但目前尚无标准治疗方案。激光疗法作为一种微创治疗选择，其疗效与安全性尚不明确。目的：系统回顾并分析现有关于激光治疗皮肤KS病变疗效与安全性的文献。方法：全面检索截至2025年8月的文献，纳入针对皮肤KS接受激光治疗且病例数≥3的随机对照试验、观察性研究及病例系列报告。从纳入研究中提取患者与疾病特征、激光治疗方案、疗效及不良事件数据。结果：本系统综述共纳入8项研究，涉及79例患者共371处治疗病灶。不同治疗方式报告的有效率差异显著，且疗效判定标准不一致。其中7项研究未报告复发情况，而第8项研究中所有病例均出现复发。总体而言，激光治疗耐受性良好，不良反应轻微，包括轻度萎缩性瘢痕、一过性炎症后改变及色素沉着。6项研究符合荟萃分析条件，汇总显著有效率为88%（95% CI：44.1–98.6%，I²=86.3%）。结论：现有数据表明激光治疗可能是皮肤KS安全有效的选择，尤其是钕：钇铝石榴石激光在展现良好疗效的同时复发率较低；但仍需进一步研究以更精确评估其疗效并规范治疗方案。
Laser Therapy for Cutaneous Kaposi Sarcoma: A Systematic Review and Meta-Analysis
肿瘤(癌症)患者之家