Background/Objectives:While smoking, areca nut chewing, and alcohol are established risk factors, Hepatitis C virus (HCV) infection has emerged as a potential risk for oral neoplasia. This study explores any association of HCV infection with oral potentially malignant disorder (OPMD) and oral cancer, following adjustment for HCV-related liver disease in a large screening cohort.Methods:Data from 37,720 participants in the Changhua Community-Based Integrated Screening Program (2005–2014) with smoking or areca nut use history were analyzed. OPMD and cirrhosis were identified at screening, while oral and liver cancers were diagnosed during follow-up. Information on demographics, lifestyle, and clinical factors, including chronic and active HCV infection, was collected. Multinomial logistic regression was used to assess associations between HCV status and disease outcomes.Results:The prevalence of hepatitis C viremia was higher in the OPMD group (4.4%) and oral cancer group (3.3%) compared to the screen-negative group (2.7%), and highest in the cirrhosis/liver cancer group (23.3%). The odds ratios of OPMD and oral cancer were 1.59 (95% CI: 1.20–2.01) and 1.22 (95% CI: 0.67–2.23), respectively, in subjects with hepatitis C viremia compared to those without. After adjusting for confounding factors, individuals with hepatitis C viremia were at increased risk of OPMD by 50% (aOR = 1.50; 95% CI: 1.17–1.92) but not a statistically significant elevated risk for oral cancer (aOR = 1.09; 95% CI: 0.59–2.01), which was possibly attenuated due to HCV-related liver disease (aOR = 11.59; 95% CI: 8.33–16.13).Conclusions:HCV infection may act as an early risk factor for OPMD, though its progression to oral cancer may occur alongside the risk of HCV-related liver diseases. Including HCV status in screening may aid early detection and secondary prevention of oral cancer in high-risk groups.
背景/目的：尽管吸烟、嚼食槟榔和饮酒是已确认的危险因素，但丙型肝炎病毒（HCV）感染已成为口腔肿瘤的潜在风险。本研究在一个大型筛查队列中，在调整HCV相关肝病的影响后，探讨HCV感染与口腔潜在恶性疾病（OPMD）及口腔癌之间的关联。 方法：分析来自彰化社区综合筛查计划（2005–2014年）的37,720名有吸烟或槟榔使用史的参与者数据。OPMD和肝硬化在筛查中被识别，而口腔癌和肝癌在随访期间被诊断。收集了包括人口统计学、生活方式和临床因素（如慢性和活动性HCV感染）的信息。采用多项逻辑回归评估HCV状态与疾病结局之间的关联。 结果：与筛查阴性组（2.7%）相比，OPMD组（4.4%）和口腔癌组（3.3%）的丙型肝炎病毒血症患病率更高，而肝硬化/肝癌组的患病率最高（23.3%）。与无丙型肝炎病毒血症的受试者相比，有丙型肝炎病毒血症的受试者患OPMD和口腔癌的比值比分别为1.59（95% CI：1.20–2.01）和1.22（95% CI：0.67–2.23）。调整混杂因素后，有丙型肝炎病毒血症的个体患OPMD的风险增加了50%（aOR = 1.50；95% CI：1.17–1.92），但口腔癌的风险未出现统计学显著升高（aOR = 1.09；95% CI：0.59–2.01），这可能因HCV相关肝病的影响而减弱（aOR = 11.59；95% CI：8.33–16.13）。 结论：HCV感染可能是OPMD的早期危险因素，但其进展为口腔癌可能与HCV相关肝病的风险同时发生。在筛查中纳入HCV状态可能有助于高危人群口腔癌的早期发现和二级预防。
肿瘤(癌症)患者之家