In healthy cells, the cytomatrix mechanics utilize mitochondrial respiration to control cytosolic motion and fine-tune the chemical processes. In cancer, the cytosolic motion is energized by glycolytic fermentation (the Warburg effect), which provides additional energy to supply the needs of the cytomatrix. Here, we describe the physical and chemical processes of the integrated and cooperative cytomatrix cytoarchitecture, in which structure and function are inseparable. The extracellular matrix is interconnected with the intracellular cytomatrix and functions as two integrated elastic solid phases. This finding led us to propose mechanisms of tumor microenvironment formation resulting from the mutational burden, in which altered proteins with corresponding post-translational modifications translocate to the cell surface, where they attract immunocompetent cells and activated fibroblasts, producing a tumor-insulating niche. This insulation disrupts cell-to-cell recognition and other signaling pathways that affect the intracellular cytomatrix, particularly actin dynamics, which influence both cell size and shape, recognized as the dedifferentiated state of cancer cells. We also discuss the perspectives of AI in cytomatrix modeling and neural network modeling, focusing on the effects of intracellular and extracellular matrices on the development of the tumor microenvironment.
在健康细胞中，细胞基质力学利用线粒体呼吸作用调控胞质运动并精细调节化学过程。而在癌细胞中，胞质运动由糖酵解发酵（瓦博格效应）供能，该过程提供额外能量以满足细胞基质的需求。本文阐述了整合协同型细胞基质架构的物理化学过程，其结构与功能具有不可分割性。细胞外基质与细胞内细胞基质相互连接，共同构成两个整合的弹性固相体系。基于此发现，我们提出了突变负荷导致肿瘤微环境形成的机制：经翻译后修饰的变异蛋白转移至细胞表面，吸引免疫活性细胞与活化成纤维细胞，从而形成肿瘤绝缘微环境。这种绝缘作用破坏了细胞间识别及其他信号通路，进而影响细胞内细胞基质——尤其是调控细胞尺寸与形态的肌动蛋白动力学，该现象被确认为癌细胞的去分化状态。本文还探讨了人工智能在细胞基质建模与神经网络建模中的应用前景，重点关注细胞内基质与细胞外基质对肿瘤微环境发展的影响。
Elastic Cytomatrix Dynamics Influences Metabolic Rate and Tumor Microenvironment Formation
肿瘤(癌症)患者之家