Chemotherapy-induced peripheral neuropathy (CIPN) impairs quality of life and may result in discontinuation of anti-neoplastic therapy. In older patients, CIPN is associated with reduced executive function, more severe pain, comorbidities and polypharmacy. The use of magnetic fields to modulate central and peripheral neurons may offer some benefit for relieving neuropathic pain, with few adverse effects. The evidence of the benefits of using transcranial magnetic stimulation (TMS) or peripheral magnetic stimulation (PMS) in patients with CIPN is evaluated in this narrative review. Improved patient-reported outcomes and more rapid nerve conduction velocities in preliminary trials suggest efficacy in patients with CIPN. The potential for additional, broader applications in CIPN includes biomarkers of progression to chronic neuropathic pain, opioid-sparing benefits, and mitigating associated depression and anxiety. Because magnetic stimulation (MS) is relatively resource intense and time consuming, requiring multiple sessions of therapy, its availability is still limited, and multi-center trials are challenging. Further research with sham-controlled clinical trials, using standardized MS techniques and outcome assessments are needed.
化疗引起的周围神经病变（CIPN）会损害生活质量，并可能导致抗肿瘤治疗中断。在老年患者中，CIPN与执行功能下降、更严重的疼痛、合并症及多重用药相关。利用磁场调节中枢及周围神经元可能对缓解神经病理性疼痛具有一定益处，且不良反应较少。本文通过叙述性综述评估了在CIPN患者中使用经颅磁刺激（TMS）或周围磁刺激（PMS）获益的证据。初步试验中患者报告结局的改善及神经传导速度的加快提示其对CIPN患者具有疗效。在CIPN中更广泛应用的潜在方向包括：作为进展为慢性神经病理性疼痛的生物标志物、减少阿片类药物使用的益处，以及缓解相关抑郁和焦虑症状。由于磁刺激（MS）相对资源密集且耗时，需要多次治疗，其可用性仍有限，多中心试验也面临挑战。未来需要通过假刺激对照临床试验，采用标准化的MS技术和结局评估开展进一步研究。
肿瘤(癌症)患者之家