Background/Objectives: With increasing survival rates in pediatric oncology, late effects, such as therapy-induced infertility, are becoming more relevant. This study evaluated the management of fertility preservation in children and adolescents with cancer at the Medical University Innsbruck between 2000 and 2018.Methods: In this retrospective monocentric study, 552 patients (0–17 years) receiving chemotherapy were analyzed. Data was extracted from the Clinical Information System and the cryopreservation database. The assessed main variables included pubertal status, sex hormone levels, and use of fertility preservation methods.Results: Fertility preservation was documented in 6.5% of patients, more frequently in males (8.9%) than females (3.2%). Sperm cryopreservation was performed in twenty-eight males, ovarian tissue cryopreservation in six females, and oocyte cryopreservation in three. Pubertal status at diagnosis was recorded in 4.9% of patients and hormone levels in 29.7%.Conclusions: The findings highlight significant gaps in systematic fertility preservation, particularly in female patients. Consistent assessment of pubertal and hormonal parameters at diagnosis is essential to inform decision-making. Standardized procedures and closer interdisciplinary collaboration are needed to ensure equitable access to fertility preservation and safeguard long-term quality of life.
背景/目的：随着儿科肿瘤患者生存率的提高，治疗相关远期并发症（如治疗所致不孕）日益受到关注。本研究评估了2000年至2018年间因斯布鲁克医科大学对儿童及青少年肿瘤患者生育力保存的管理情况。方法：这项回顾性单中心研究分析了552例（0-17岁）接受化疗的患者数据，资料来源于临床信息系统及冷冻保存数据库。评估的主要变量包括青春期状态、性激素水平及生育力保存方法的应用。结果：6.5%的患者有生育力保存记录，男性（8.9%）显著高于女性（3.2%）。具体包括28例男性精子冷冻、6例女性卵巢组织冷冻及3例卵母细胞冷冻。仅4.9%的患者在诊断时记录了青春期状态，29.7%检测了激素水平。结论：研究结果揭示了系统性生育力保存存在显著不足，尤其在女性患者中。诊断时持续评估青春期状态和激素参数对临床决策至关重要。需要建立标准化流程并加强跨学科协作，以保障生育力保存的公平可及，维护患者长期生活质量。
肿瘤(癌症)患者之家