文章：

分化型甲状腺癌（WDTC）中肿瘤病灶数量与超声模式及再手术率的关联性——单中心分析

Association of a Number of Tumor Foci with Ultrasound Patterns and Reoperation Rate in Well-Differentiated Thyroid Cancer (WDTC)—A Single-Center Analysis

原文发布日期：7 November 2025

DOI: 10.3390/cancers17223595

类型: Article

开放获取: 是

英文摘要：

Background: Suspicious ultrasound patterns are essential for the accurate preoperative assessment of thyroid cancer (TC). The number of tumor foci may serve as an additional parameter, particularly when considered in association with ultrasound patterns and the reoperation rate. Methods: We conducted a retrospective analysis of 665 well-differentiated TC (WDTC) patients treated between 2008 and 2024. The analysis included preoperative data, ultrasound patterns (hypoechogenicity, microcalcifications, high vascularity, and irregular tumor shape or margins), and histopathological findings regarding the number of tumor foci and reoperation rates, additionally stratified by TNM stage and sex. Results: A statistically significant association was observed between the number of tumor foci and the mean number of ultrasound patterns (p< 0.05). The highest mean number of patterns was found with ≥4 foci (SD: 2.50 ± 1.20). However, this relationship was not linear, as in each focus category (1, 2, 3, and ≥4), the greatest number of ultrasound patterns consistently predominated. No significant association was found between a higher number of foci and a complete set of ultrasound patterns (p= 0.273) or the reoperation rate (p= 0.469). Analyses stratified by TNM stage and sex also did not reveal any significant differences (p> 0.05). Conclusions: Although the number of tumor foci demonstrates an association with ultrasound patterns, the lack of a consistent linear correlation and the absence of an impact on reoperation rates suggest that this parameter may provide limited additional clinical value beyond the general concept of multifocality.

摘要翻译： 

背景：可疑的超声征象对于甲状腺癌（TC）的准确术前评估至关重要。肿瘤病灶数量可作为一项补充参数，尤其当结合超声征象及再手术率进行综合考量时。方法：我们对2008年至2024年间收治的665例分化型甲状腺癌（WDTC）患者进行回顾性分析，纳入术前资料、超声征象（低回声、微钙化、高血供及肿瘤形态/边缘不规则）以及关于肿瘤病灶数量和再手术率的组织病理学结果，并进一步按TNM分期和性别进行分层分析。结果：肿瘤病灶数量与超声征象平均数量存在统计学显著关联（p<0.05）。≥4个病灶组的超声征象平均数量最高（标准差：2.50±1.20）。然而该关联并非线性关系，因为在各病灶数量组（1、2、3及≥4个）中，超声征象数量最多的类别始终占主导地位。较多病灶数量与完整超声征象组合（p=0.273）或再手术率（p=0.469）均未呈现显著关联。按TNM分期和性别分层分析亦未发现显著差异（p>0.05）。结论：虽然肿瘤病灶数量与超声征象存在关联，但由于缺乏稳定的线性相关性且对再手术率无显著影响，提示该参数在超越多灶性一般概念之外可能提供的临床附加价值有限。

原文链接：

Association of a Number of Tumor Foci with Ultrasound Patterns and Reoperation Rate in Well-Differentiated Thyroid Cancer (WDTC)—A Single-Center Analysis