文章：

胰腺导管腺癌的分子病理学

Molecular Pathology of Pancreatic Ductal Adenocarcinoma

原文发布日期：2 November 2025

DOI: 10.3390/cancers17213549

类型: Article

开放获取: 是

英文摘要：

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that frequently presents at an advanced stage with limited effective treatment options and a dismal prognosis. It is a highly heterogenous disease driven by various genetic and epigenetic alterations. Recent advances in sequencing modalities have significantly improved our understanding of the genetics of PDAC, which could lead to promising and novel therapeutic strategies. In this review, we summarize the most up-to-date literature on the molecular landscape of PDAC and its precursor lesions, as well as recent advances in targeted therapy.

摘要翻译： 

胰腺导管腺癌（PDAC）是一种侵袭性癌症，常在晚期才被发现，有效治疗手段有限且预后极差。该疾病具有高度异质性，由多种遗传和表观遗传改变驱动。近年来，测序技术的进步显著提升了我们对PDAC遗传学特征的理解，这有望催生具有前景的新型治疗策略。本文综述了关于PDAC及其癌前病变分子特征的最新研究进展，并总结了靶向治疗领域的最新成果。

原文链接：

Molecular Pathology of Pancreatic Ductal Adenocarcinoma