Brain tumor-related epilepsy (BTRE) is a common and debilitating symptom of central nervous system (CNS) tumors. The epileptogenic zone, defined as cortex responsible for seizure generation, is located at the peritumoral region for most tumors, and lower-grade intrinsic brain tumors have the highest seizure incidence. Surgery is often the most effective treatment for the reduction in seizures in BTRE. However, surgical decisions have historically often been made exclusively for oncologic reasons, with less emphasis on seizure control. Surgical approaches for all tumor types are reviewed, highlighting relevant risk factors. Adjunctive tools during surgery, such as intraoperative electrocorticography (ECoG), may help identify and remove surrounding brain areas which are epileptogenic. Minimally invasive surgery is also gaining traction, given its utility in treating seizures deep-seated tumors. This review explores epileptogenic brain tumors, surgery for BTRE, and emerging strategies to better achieve seizure control.
脑肿瘤相关性癫痫是中枢神经系统肿瘤常见且具有致残性的症状。对于大多数肿瘤而言，致痫区（即诱发癫痫发作的皮质区域）位于瘤周区域，其中低级别内在性脑肿瘤的癫痫发生率最高。手术治疗通常是减少脑肿瘤相关性癫痫发作最有效的方法。然而，历史上手术决策往往仅基于肿瘤学考量，对癫痫控制的重视相对不足。本文系统回顾了各类肿瘤的手术治疗策略，重点分析了相关风险因素。术中辅助工具如皮层脑电图监测，有助于识别并切除致痫的周围脑区。鉴于其在治疗深部肿瘤所致癫痫方面的优势，微创手术也日益受到重视。本综述探讨了致痫性脑肿瘤、脑肿瘤相关性癫痫的手术治疗以及实现更佳癫痫控制的新兴策略。
Surgical Treatment of Brain Tumor-Related Epilepsy: Current and Emerging Strategies
肿瘤(癌症)患者之家