文章：

每日摄入芹菜素可预防暴露于类空间辐射的雄性C57BL/6J小鼠发生急性淋巴瘤/淋巴细胞白血病

Daily Consumption of Apigenin Prevents Acute Lymphoma/Lymphoblastic Leukemia in Male C57BL/6J Mice Exposed to Space-like Radiation

原文发布日期：31 October 2025

DOI: 10.3390/cancers17213513

类型: Article

开放获取: 是

英文摘要：

Introduction: The work presented here is part of our study series aimed at investigating the countermeasure effectiveness of apigenin (AP) against both early and late effects of heavy silicon (28Si) on the same cohort of exposed male C57BL/6 mice. We previously reported the countermeasure of AP against28Si-induced early effects of28Si ions. This section focuses on the protective effects of AP on late effects, specifically on the induction of acute lymphoma/lymphoblastic leukemia. Method: Mice received a diet containing 20 mg/kg body weight of AP for five days before and after total-body irradiation with either 0 or 0.5 Gy of 260 MeV28Si ions. They were divided into four groups based on AP intake and irradiation status. At one-week after irradiation, six mice from each group were euthanized to assess AP’s effectiveness against early inflammation (in the bone marrow and gut tissues) and gut dysbiosis. The remaining mice were monitored until approximately 770 days of age. Incidence rates were analyzed using Chi-Square tests, while survival data were evaluated with Kaplan–Meier plots and log-rank tests, setting significance atp≤ 0.05. Results: At 770 days, survival rates were 37% for28Si-exposed mice and 63% for those consuming AP, despite irradiation. There was a 2.57-fold increase in acute lymphoma/lymphoblastic leukemia incidence among28Si-exposed mice not receiving AP compared to controls and AP-fed mice. Together with our previous report on the countermeasure activity of AP against early effects, these findings suggest that the gut–bone marrow axis plays an important role in28Si-induced acute lymphoma/lymphoblastic leukemia. Conclusion: Our findings demonstrate that AP is an effective means of tackling the challenges posed by space radiation, and it has the potential to revolutionize protection in this critical area.

摘要翻译： 

引言：本研究是我们系列工作的一部分，旨在探讨芹菜素对重硅离子（28Si）所致早期及晚期损伤的防护效果。实验采用同一批暴露于28Si的雄性C57BL/6小鼠。我们此前已报道了芹菜素对28Si离子所致早期损伤的防护作用，本节重点研究其对晚期效应——特别是急性淋巴瘤/淋巴母细胞白血病诱导的防护效果。方法：小鼠在接受0或0.5 Gy 260 MeV 28Si离子全身照射前后五天，持续摄入含20 mg/kg体重芹菜素的饲料。根据芹菜素摄入和照射状态将小鼠分为四组。照射后一周，每组处死六只小鼠以评估芹菜素对早期炎症（骨髓和肠道组织）及肠道菌群失调的防护效果。其余小鼠持续观察至约770日龄。采用卡方检验分析发病率，通过Kaplan-Meier曲线和对数秩检验评估生存数据，显著性水平设定为p≤0.05。结果：在770日龄时，尽管接受照射，28Si暴露组小鼠存活率为37%，而摄入芹菜素组存活率达63%。未摄入芹菜素的28Si暴露组小鼠急性淋巴瘤/淋巴母细胞白血病发病率较对照组及芹菜素喂养组增加2.57倍。结合我们先前关于芹菜素对早期损伤防护作用的报告，这些发现表明肠道-骨髓轴在28Si诱导的急性淋巴瘤/淋巴母细胞白血病中发挥重要作用。结论：我们的研究证明芹菜素是应对空间辐射挑战的有效手段，有望在这一关键领域带来革命性的防护突破。

原文链接：

Daily Consumption of Apigenin Prevents Acute Lymphoma/Lymphoblastic Leukemia in Male C57BL/6J Mice Exposed to Space-like Radiation