文章：

作者关于颌骨中央性巨细胞肉芽肿有效治疗方案的临床研究方案

Authors’ Protocol of Central Giant Cell Granuloma Effective Treatment in the Jawbone

原文发布日期：31 October 2025

DOI: 10.3390/cancers17213510

类型: Article

开放获取: 是

英文摘要：

Background: Central giant cell granuloma of the jaw is a benign but potentially aggressive lesion that can cause pain, facial deformity, tooth loss, and jaw destruction. Many treatment methods are described in the literature, but the less invasive ones are associated with a higher recurrence rate. For several decades, extensive bone resection procedures have been the most effective treatment to date. This study aimed to evaluate a minimally invasive treatment protocol combining multiple weekly intralesional steroid injections with surgical removal of residual tumor tissue and chemical cauterization using Carnoy’s solution. Methods: Thirteen patients with histologically confirmed central giant cell granulomas of the jaws were treated according to the protocol, including weekly triamcinolone injections and, when necessary, fenestration of the cortical bone to access residual lesions. Patients were monitored clinically and radiologically over six years, with reconstruction of bone defects using autogenous grafts and platelet-rich fibrin. Results: The treatment effectively reduced tumor size, restored cortical bone, and allowed preservation of jaw structure. Only one recurrence was observed, and complications were minor and transient. The protocol was equally effective for both aggressive and non-aggressive lesions, regardless of patient age or comorbidities. Conclusions: These findings suggest that combining pharmacological and surgical approaches with chemical cauterization provides a safe, effective, and tissue-preserving strategy for managing central giant cell granulomas, minimizing recurrence while reducing surgical morbidity.

摘要翻译： 

背景：颌骨中心性巨细胞肉芽肿是一种良性但具有潜在侵袭性的病变，可导致疼痛、面部畸形、牙齿脱落及颌骨破坏。文献中记载了多种治疗方法，但微创治疗方式的复发率较高。数十年来，广泛性骨切除术一直是目前最有效的治疗手段。本研究旨在评估一种微创治疗方案，该方案结合了每周多次病灶内类固醇注射、手术切除残余肿瘤组织以及使用卡诺伊溶液进行化学烧灼。 方法：13例经组织学确诊为颌骨中心性巨细胞肉芽肿的患者接受了该方案治疗，包括每周注射曲安奈德，并在必要时开窗切除皮质骨以处理残余病灶。患者接受了为期六年的临床和影像学随访，骨缺损采用自体骨移植和富血小板纤维蛋白进行修复。 结果：该治疗方案有效缩小了肿瘤体积，恢复了皮质骨结构，并保留了颌骨形态。仅观察到一例复发，并发症轻微且短暂。无论患者年龄或合并症情况如何，该方案对侵袭性和非侵袭性病变均具有同等疗效。 结论：研究结果表明，结合药物与手术方法并辅以化学烧灼，为治疗颌骨中心性巨细胞肉芽肿提供了一种安全、有效且能保留组织的策略，在降低复发率的同时减少了手术创伤。

原文链接：

Authors’ Protocol of Central Giant Cell Granuloma Effective Treatment in the Jawbone