文章：

硬纤维瘤——来自转诊中心的经验，第一部分：多学科综述与实践建议

Desmoid Tumors—Experience from a Referral Center, Part 1: Multidisciplinary Review and Practical Recommendations

原文发布日期：29 October 2025

DOI: 10.3390/cancers17213470

类型: Article

开放获取: 是

英文摘要：

Desmoid tumors (DTs), also known as aggressive fibromatosis, are rare neoplasms characterized by local invasiveness and a high risk of recurrence, despite their lack of metastatic potential. The management of these tumors remains challenging due to their unpredictable behavior and heterogeneous presentations. In this two-part study, we first provide a comprehensive review of the scientific evidence on diagnosis and emerging therapeutic strategies for DT. In the second part, we will present a retrospective analysis of our experience at a national reference center for sarcoma treatment, focusing on diagnostic strategies, therapeutic interventions, and clinical outcomes.

摘要翻译： 

硬纤维瘤（Desmoid tumors, DTs），亦称侵袭性纤维瘤病，是一种罕见肿瘤，其特征为局部侵袭性强且复发风险高，但无转移潜能。由于该肿瘤具有不可预测的生物学行为和异质性临床表现，其临床管理仍具挑战性。本研究分为两部分：首先系统综述硬纤维瘤诊断及新兴治疗策略的科学证据；第二部分将基于国家肉瘤诊疗参考中心的临床实践，回顾性分析诊断策略、治疗干预及临床结局。

原文链接：

Desmoid Tumors—Experience from a Referral Center, Part 1: Multidisciplinary Review and Practical Recommendations