Objectives:Endometrial carcinoma is the most common gynaecological cancer in developed countries, with both incidence and mortality rates continuing to rise globally. For women of reproductive age diagnosed with early-stage disease or endometrial intraepithelial neoplasia, fertility-preserving treatment should be considered to maintain the possibility of future childbearing. Effective fertility-sparing management requires a multidisciplinary approach that includes patient education, reduction in risk factors, accurate molecular and histological classification to guide targeted therapies, assisted reproductive technologies to improve early conception rates, and attention to the psycho-sexual well-being of patients to support treatment adherence.Methods:This retrospective cohort study analysed the clinicopathological features and treatment outcomes of thirteen patients who received fertility-preserving therapy between 2018 and 2023.Results:The mean age of the patients (n= 13) was 34.4 years, with a range of 20 to 41 years. The overall treatment response rate was 76.9%, including 69.2% complete and 7.7% partial responses. Stable disease was observed in 15.4% of cases, while progression occurred in 7.7%. Among those who achieved complete remission, in vitro fertilisation (IVF) was initiated in four cases, with two ongoing as of the time of data analysis. In one of the cases, after two unsuccessful assisted reproductive attempts, spontaneous conception occurred, resulting in the birth of a child.Conclusions:Our findings support the feasibility and success of fertility-preserving treatment in carefully selected patients, allowing the preservation of reproductive potential alongside oncological care.
目的：子宫内膜癌是发达国家最常见的妇科恶性肿瘤，其发病率和死亡率在全球范围内持续上升。对于诊断为早期疾病或子宫内膜上皮内瘤变的育龄期女性，应考虑保留生育功能的治疗方案，以维持未来生育的可能性。有效的保留生育功能管理需要多学科协作，包括患者教育、风险因素控制、通过精确的分子和组织学分类指导靶向治疗、应用辅助生殖技术提高早期妊娠率，以及关注患者的心理与性健康以提升治疗依从性。 方法：本回顾性队列研究分析了2018年至2023年间接受保留生育功能治疗的13例患者的临床病理特征及治疗结局。 结果：13例患者平均年龄34.4岁（范围20-41岁）。总体治疗应答率为76.9%，其中完全缓解率69.2%，部分缓解率7.7%。疾病稳定占15.4%，疾病进展占7.7%。在获得完全缓解的患者中，4例启动了体外受精治疗，截至数据分析时2例仍在进行中。其中1例在两次辅助生殖尝试未成功后实现自然受孕并成功分娩。 结论：本研究结果支持在严格筛选的患者中实施保留生育功能治疗的可行性与成功性，能够在肿瘤治疗的同时有效保留生殖潜能。
肿瘤(癌症)患者之家