文章：

三阴性乳腺癌的双靶点治疗策略：机制解析与临床潜力

Dual-Target Therapeutic Strategies in Triple-Negative Breast Cancer: Mechanistic Insights and Clinical Potential

原文发布日期：28 October 2025

DOI: 10.3390/cancers17213455

类型: Article

开放获取: 是

英文摘要：

Triple-negative breast cancer (TNBC) is an aggressive malignancy marked by high heterogeneity, metastatic potential, and a lack of established targeted therapies. This review explores emerging dual-target strategies that concurrently address key biological mechanisms in TNBC, including DNA damage repair, cell cycle regulation, epigenetic modulation, metabolic reprogramming, and immune microenvironment remodeling. By acting on multiple signaling nodes, these strategies demonstrate enhanced efficacy, an ability to overcome resistance, and a potential to reverse immunosuppression. Although challenges in patient selection, toxicity, and mechanistic understanding remain—with most strategies in preclinical or early clinical development—this approach offers a promising path toward precision medicine and improved outcomes for TNBC patients.

摘要翻译： 

三阴性乳腺癌（TNBC）是一种侵袭性恶性肿瘤，具有高度异质性、转移潜能和缺乏成熟靶向疗法的特点。本综述探讨了新兴的双靶点策略，这些策略同时针对TNBC的关键生物学机制，包括DNA损伤修复、细胞周期调控、表观遗传调控、代谢重编程和免疫微环境重塑。通过作用于多个信号节点，这些策略展现出增强的疗效、克服耐药性的能力以及逆转免疫抑制的潜力。尽管在患者选择、毒性和机制理解方面仍存在挑战——且大多数策略尚处于临床前或早期临床开发阶段——但这一方法为TNBC患者的精准医疗和改善预后提供了前景广阔的新路径。

原文链接：

Dual-Target Therapeutic Strategies in Triple-Negative Breast Cancer: Mechanistic Insights and Clinical Potential