Background: Adolescents and young adults (15–39 years of age at time of diagnosis: AYA) with sarcoma are a unique patient population. The objective of this review is to examine the literature outlining the benefits of proton beam therapy (PBT) for treatment of AYA sarcoma patients, barriers to PBT, evaluation of AYA-specific considerations and challenges, and exploration of future opportunities for improvements in care.Methods: An electronic search was conducted using databases and online search engines, primarily PubMed. The search criteria included studies and reviews completed from 2015 to 2025.Results:57 articles were reviewed and categorized into sections: PBT for the treatment of the AYA patient, barriers to PBT, AYA-specific considerations and challenges, and future directions for the care of an AYA patient.Conclusions: Through this review, PBT can be deemed necessary when treating AYA sarcoma patients with radiation therapy to decrease long-term therapy-related toxicities. Furthermore, considerations for caring for an AYA sarcoma patient must extend beyond evidence-based treatment plans and must embrace the patient as a whole person through acknowledgement of the challenging impact on physical, mental, and social well-being from symptoms to diagnosis, diagnosis to treatment, and treatment to survivorship.
背景：青少年与年轻成人（诊断时年龄15-39岁：AYA）肉瘤患者是一个独特的患者群体。本综述旨在梳理相关文献，探讨质子束治疗（PBT）对AYA肉瘤患者的临床获益、实施PBT面临的障碍、针对AYA群体的特殊考量与挑战，并探索未来改善照护的潜在方向。 方法：通过数据库及在线搜索引擎（以PubMed为主）进行电子检索。检索标准涵盖2015年至2025年间完成的研究与综述。 结果：共纳入57篇文献，并将其归纳为以下主题：PBT在AYA患者治疗中的应用、PBT的实施障碍、AYA群体的特殊考量与挑战，以及AYA患者照护的未来发展方向。 结论：本综述表明，对需要接受放射治疗的AYA肉瘤患者而言，PBT对于降低长期治疗相关毒性具有必要性。此外，对AYA肉瘤患者的照护需超越循证治疗方案的范畴，必须将患者视为完整的个体，充分关注从症状出现到确诊、从诊断到治疗、从治疗到生存期全过程中，疾病对其生理、心理及社会福祉造成的多重挑战。
肿瘤(癌症)患者之家