Background/Objectives: The aim of this study was to evaluate the association between serum iodine (I) levels and kidney cancer mortality. The role of serum iodine levels in relation to 8-year survival rates in survivors of kidney cancer has not previously been established. In this prospective study, we analyzed 284 consecutive, unselected survivors of kidney cancer and determined their 8-year survival in relation to iodine levels. Methods: Micronutrient levels were measured using inductively coupled plasma mass spectrometry (ICP-MS). Each survivors of kidney cancer was assigned to one of four groups based on the quartile distribution of iodine levels, ranked in ascending order. The multivariable models included covariates such as age at diagnosis, sex, smoking status, type of surgery, histopathological classification and serum levels of selenium, zinc, copper and the zinc-to-copper ratio. Results: We observed that survivors of kidney cancer with serum iodine levels in quartiles III and IV had significantly higher all-cause mortality compared to those in quartile II (reference quartile) (HR = 2.83;p= 0.012; HR = 2.64;p= 0.017). Furthermore, multivariable analysis revealed a significant association between serum iodine levels (quartiles III and IV vs. quartile II) and mortality due to kidney cancer progression (HR = 4.17;p= 0.031; HR = 3.94;p= 0.038, respectively). This association was significant only among men in quartile IV (HR = 16.5;p= 0.027). Additionally a positive association was observed between iodine levels in quartile IV and all-cause mortality from non–kidney cancer–related deaths (HR = 5.41;p= 0.05). Conclusions: To our knowledge, this study is the first investigation of relationship between serum iodine levels and survival of survivors of kidney cancer.
背景/目的：本研究旨在评估血清碘水平与肾癌死亡率之间的关联。血清碘水平与肾癌幸存者8年生存率的关系此前尚未明确。在这项前瞻性研究中，我们连续纳入284例未经筛选的肾癌幸存者，根据其碘水平分析其8年生存状况。方法：采用电感耦合等离子体质谱法（ICP-MS）测定微量营养素水平。根据碘水平的四分位数分布（按升序排列），将每位肾癌幸存者归入四个组别之一。多变量模型纳入的协变量包括确诊年龄、性别、吸烟状况、手术类型、组织病理学分类以及血清硒、锌、铜水平和锌铜比值。结果：研究发现，与处于第二四分位数（参照组）的肾癌幸存者相比，血清碘水平处于第三和第四四分位数的患者全因死亡率显著升高（风险比[HR] = 2.83，p=0.012；HR = 2.64，p=0.017）。此外，多变量分析显示，血清碘水平（第三、四分位数与第二四分位数相比）与肾癌进展导致的死亡率存在显著关联（HR分别为4.17，p=0.031；3.94，p=0.038）。这种关联仅在处于第四四分位数的男性中显著（HR = 16.5，p=0.027）。同时，第四四分位数的碘水平与非肾癌相关死亡的全因死亡率呈正相关（HR = 5.41，p=0.05）。结论：据我们所知，本研究首次探讨了血清碘水平与肾癌幸存者生存率之间的关系。
Serum Iodine Levels and 8-Year Survival in Patients After Kidney Cancer Diagnosis
肿瘤(癌症)患者之家