文章：

核心解剖学问题：中枢神经系统邻近边界区域淋巴瘤的治疗策略

The Central Anatomical Question: Treatment of Lymphoma Within Border-Zone Anatomical Sites Adjacent to the Central Nervous System

原文发布日期：21 October 2025

DOI: 10.3390/cancers17203392

类型: Article

开放获取: 是

英文摘要：

Lymphomas involving the central nervous system (CNS) have worse outcomes, including both primary and secondary CNS lymphomas, which are associated with poorer overall survival outcomes. The World Health Organization classifies CNS lymphoma as arising from the brain, leptomeninges, and spinal cord, but this simplified CNS anatomical definition fails to incorporate areas of ambiguity that can be clinically relevant for treatment decision making. In this article, we review the anatomical boundaries of CNS lymphoma within select border-zone biological structures located at the CNS borders in order to gain a consensus working definition of CNS disease boundaries. We review anatomical localizations with border-zone CNS boundaries, including the dura, cavernous sinus, circumventricular organs, pituitary gland, and cranial nerves. Though some portions of the eye would be considered CNS and others extra-CNS, recommendations for this structure are outside the scope of this review. Through this review, we examine the impact of lymphomatous invasion on select CNS-bordering anatomical structures, aiming to better define treatment categorization as CNS or extra-CNS, with a focus on B cell lymphoma types.

摘要翻译： 

累及中枢神经系统（CNS）的淋巴瘤预后较差，包括原发性与继发性中枢神经系统淋巴瘤，均与较低的总生存率相关。世界卫生组织将中枢神经系统淋巴瘤定义为起源于脑组织、软脑膜和脊髓的肿瘤，但这一简化的解剖学定义未能涵盖临床治疗决策中可能涉及的概念模糊区域。本文通过探讨位于中枢神经系统边界的特定交界区生物结构，重新审视中枢神经系统淋巴瘤的解剖学边界，以期就疾病范围达成共识性工作定义。我们重点分析了具有交界区特征的中枢神经系统边界解剖定位，包括硬脑膜、海绵窦、室周器官、垂体及颅神经。尽管眼部的部分结构可被视为中枢神经系统范畴，其余部分则属外周神经系统，但针对该结构的详细讨论不在本文综述范围内。通过系统梳理，本研究旨在探究淋巴瘤浸润对特定中枢神经系统交界解剖结构的影响，重点关注B细胞淋巴瘤类型，以更精准界定其治疗分类归属中枢神经系统或外周神经系统范畴。

原文链接：

The Central Anatomical Question: Treatment of Lymphoma Within Border-Zone Anatomical Sites Adjacent to the Central Nervous System