Gastric cancer (GC) remains the most common malignancy and the main cause of cancer-related death worldwide. Due to its asymptomatic beginning, most gastric cancer cases are diagnosed in the advanced stages, which is connected with poor outcomes. Therefore, there is an urgent need for the development of early preventive and screening strategies for GC. A full understanding of GC pathogenesis, including examining key factors participating in cancer progress, is important. MUC1 is a glycoprotein that is highly overexpressed in most epithelial tumors, including gastric tumors. MUC1 presents a specifically altered glycosylation pattern, which is important for the creation of a cancerous environment. This mucin has been proposed as a biomarker for predicting GC outcomes. This review summarizes the involvement of MUC1 in GC progression.
胃癌（GC）仍是全球范围内最常见的恶性肿瘤及癌症相关死亡的主要原因。由于其发病初期无明显症状，多数胃癌病例在确诊时已进入晚期，这与不良预后密切相关。因此，亟需制定胃癌的早期预防与筛查策略。全面理解胃癌的发病机制，包括探究参与癌症进展的关键因素至关重要。MUC1是一种在包括胃肿瘤在内的大多数上皮性肿瘤中高度过表达的糖蛋白。MUC1呈现出特异性改变的糖基化模式，这对肿瘤微环境的形成具有重要意义。该黏蛋白已被提议作为预测胃癌预后的生物标志物。本文综述了MUC1在胃癌进展中的作用机制。
肿瘤(癌症)患者之家