Background/Objectives: Solitary plasmacytoma of bone (SPB) results from abnormal proliferation of plasma cells and accounts for 2–5% of all plasmacytic malignancies. Radiation therapy is the standard of care in treating SPB due to its efficacy in controlling disease progression and optimizing patient survival. However, prior studies have highlighted disparities in radiation therapy receipt among various cancer types. In this study, we aim to investigate whether similar sociodemographic and clinical disparities exist in the treatment of SPB through use of the Surveillance, Epidemiology, and End Results (SEER) database.Methods: The SEER database was queried for biopsy-confirmed cases of SPB between 2000 and 2021 using the ICD-O-3 histology code 9731/3 and primary site codes C40.0–41.9. Chi-square tests, Fisher’s exact tests, and multivariable logistic regression were completed using SPSS v29.0.2, with significance set top< 0.05.Results: A total of 4139 patients were identified, of which 75.3% received treatment with radiation therapy. Multivariable analysis revealed that low-income patients making less than $74,999 annually (aOR 0.80, 95% CI 0.67–0.97), as well as those from non-Hispanic Asian/Pacific Islander (aOR 0.49, 95% CI 0.33–0.73) and Hispanic (aOR 0.77, 95% CI 0.60–0.98) racial and ethnic groups, were significantly less likely to receive radiation therapy.Conclusions: These findings reveal notable disparities in radiation therapy utilization for SPB patients based on income and race and ethnicity, emphasizing the need for interventions to address systemic inequities, improve access to care, and ensure that all patients receive high-quality cancer care to optimize long-term outcomes.
背景/目的：骨孤立性浆细胞瘤源于浆细胞异常增殖，占所有浆细胞恶性肿瘤的2–5%。放射治疗因其在控制疾病进展和优化患者生存方面的有效性，成为治疗该病的标准方案。然而，既往研究已指出不同癌症类型在放射治疗接受率上存在差异。本研究旨在利用监测、流行病学和最终结果（SEER）数据库，探讨在骨孤立性浆细胞瘤的治疗中是否存在类似的社会人口学及临床差异。 方法：通过ICD-O-3组织学代码9731/3及原发部位代码C40.0–41.9，从SEER数据库中提取2000年至2021年间经活检确诊的骨孤立性浆细胞瘤病例。使用SPSS v29.0.2软件进行卡方检验、Fisher精确检验及多变量逻辑回归分析，显著性水平设定为p<0.05。 结果：共纳入4139例患者，其中75.3%接受了放射治疗。多变量分析显示，年收入低于74,999美元的低收入患者（调整后比值比aOR 0.80，95%置信区间0.67–0.97），以及非西班牙裔亚洲/太平洋岛民（aOR 0.49，95% CI 0.33–0.73）和西班牙裔（aOR 0.77，95% CI 0.60–0.98）种族/族裔群体，接受放射治疗的可能性显著较低。 结论：这些发现揭示了骨孤立性浆细胞瘤患者在接受放射治疗方面存在基于收入及种族/族裔的显著差异，强调需通过系统性干预措施解决医疗不平等问题，改善治疗可及性，确保所有患者均能获得高质量的癌症治疗，以优化长期预后。
肿瘤(癌症)患者之家