文章：

晚期胆道癌：化疗失败后三线及其他治疗领域的探索

Advanced Biliary Tract Cancer: Exploration of Third-Line and Other Therapeutic Areas After Failure of Chemotherapy Alone

原文发布日期：9 October 2025

DOI: 10.3390/cancers17193268

类型: Article

开放获取: 是

英文摘要：

Biliary tract cancer (BTC) is a highly aggressive malignancy with an extremely poor prognosis and a gradually increasing incidence, warranting increased clinical attention. The majority of BTC patients are diagnosed at an unresectable stage, making systemic therapy—including first-line and subsequent treatments—critical for outcomes. However, due to disparities in medical resources and limited understanding of the disease, outcomes following first- and second-line therapies remain suboptimal. In this context, third-line treatment offers a potential opportunity to further extend patient survival, although challenges such as poor treatment tolerance and significant drug-related toxicities remain. A rational integration of chemotherapy, targeted therapy, immunotherapy, and novel radiotherapy techniques may constitute a standardized third-line therapeutic strategy for BTC. This review aims to discuss potential therapeutic adaptations and options in the setting where conventional chemotherapy has failed.

摘要翻译： 

胆道癌是一种高度侵袭性的恶性肿瘤，预后极差且发病率呈逐渐上升趋势，值得临床给予更多关注。大多数胆道癌患者在确诊时已处于不可切除阶段，这使得系统治疗——包括一线及后续治疗——对患者预后至关重要。然而，由于医疗资源分布不均及对该疾病认知有限，一线和二线治疗后的疗效仍不尽如人意。在此背景下，三线治疗为延长患者生存期提供了潜在机会，尽管仍面临治疗耐受性差和药物相关毒性显著等挑战。合理整合化疗、靶向治疗、免疫治疗及新型放疗技术，可能构成胆道癌标准化的三线治疗策略。本文旨在探讨传统化疗失败情况下的潜在治疗调整方案及选择。

原文链接：

Advanced Biliary Tract Cancer: Exploration of Third-Line and Other Therapeutic Areas After Failure of Chemotherapy Alone