文章：

骨转移患者运动干预对躯体功能与功能自主性的影响——一项系统综述

Movement-Based Interventions in Patients Affected by Bone Metastases: Impact on Physical Function and Functional Autonomy—A Systematic Review

原文发布日期：9 October 2025

DOI: 10.3390/cancers17193266

类型: Article

开放获取: 是

英文摘要：

Background:Bone metastases are a common complication in patients with advanced cancer. These patients often experience a decline in physical function and autonomy, particularly in the ability to perform Activities of Daily Living, and structured movement-based interventions may represent an important supportive strategy. The aim of this study is to describe the available evidence regarding the impact of physical activity and exercise interventions on functional status and ADL performance in patients with bone metastases.Methods:A systematic literature review was conducted in PubMed, Scopus, Embase, Web of Science, and CINAHL database up to March 2025 and reported according to PRISMA guidelines. Eligible studies included adults (≥18 years) with confirmed bone metastases who underwent physical activity interventions designed to enhance functional status and ADLs. Studies’ methodological quality was assessed using the Joanna Briggs Institute critical appraisal tools, selected according to study design.Results:Eleven studies were included: four randomized controlled trials, four quasi-experimental studies, one randomized feasibility trial, one cross-sectional observational study, and one case report. Despite heterogeneity in intervention type, duration, and outcome measures, most studies reported improvements in physical function, including mobility, muscle strength, walking capacity, and endurance, as well as enhanced performance in ADLs and reductions in fatigue. No serious adverse events were reported.Conclusions:Structured physical activity appears safe and may improve function and independence in patients with bone metastases. These findings support the integration of individualized exercise programs into multidisciplinary supportive care.

摘要翻译： 

背景：骨转移是晚期癌症患者的常见并发症。此类患者常出现身体功能和自主能力下降，尤其是在执行日常生活活动方面，而结构化的运动干预可能是一项重要的支持性策略。本研究旨在总结关于体力活动和运动干预对骨转移患者功能状态及日常生活活动能力影响的现有证据。 方法：在PubMed、Scopus、Embase、Web of Science和CINAHL数据库中检索截至2025年3月的文献，并依据PRISMA指南进行系统综述。纳入标准为针对确诊骨转移的成年患者（≥18岁）、旨在改善功能状态和日常生活活动能力的体力活动干预研究。根据研究设计选用乔安娜布里格斯研究所关键评估工具对研究方法学质量进行评价。 结果：共纳入11项研究：包括4项随机对照试验、4项类实验研究、1项随机可行性试验、1项横断面观察性研究和1例病例报告。尽管干预类型、持续时间和结局指标存在异质性，但多数研究报道了身体功能的改善，包括活动能力、肌肉力量、步行能力和耐力，同时日常生活活动能力得到提升，疲劳程度减轻。未报告严重不良事件。 结论：结构化体力活动对骨转移患者具有安全性，并可能改善其功能状态与独立能力。这些发现支持将个体化运动方案纳入多学科支持性治疗体系。

原文链接：

Movement-Based Interventions in Patients Affected by Bone Metastases: Impact on Physical Function and Functional Autonomy—A Systematic Review